CAS No. 1934259-00-3
Batch:
Purity:99.03
Chemical Structure
Check the
limertinib
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | N-[5-[[5-chloro-4-(naphthalen-2-ylamino)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide | |
|---|---|---|
| CAS Number | 1934259-00-3 | |
| Molecular Formula |
C29H32ClN7O2 |
|
| Molecular Weight (MW) | 546.06 | |
| InChIKey | QHPVTCLSVVUPOF-UHFFFAOYSA-N |
Biological Activity
Limertinib (ASK120067) is an irreversible, third-generation kinase inhibitor targeting EGFR T790M (IC= with high selectivity over wild-type EGFR (IC=. By blocking mutant EGFR phosphorylation and inhibiting downstream AKT pathway signaling, limertinib effectively attenuates oncogenic signals, leading to potent anti-proliferation activity and apoptosis in non-small cell lung cancer tumor cells. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(183.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.