CAS No. 4431-01-0

Batch: Purity:
Ligustilide Chemical Structure
Chemical Structure
Check the Ligustilide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3Z)-3-butylidene-4,5-dihydro-2-benzofuran-1-one
CAS Number 4431-01-0
Molecular Formula

C12H14O2
Molecular Weight (MW) 190.24
SMILES CCCC=C1C2=C(C=CCC2)C(=O)O1
InChIKey IQVQXVFMNOFTMU-FLIBITNWSA-N

Ordering Information

Biological Activity

Ligustilide is a bioactive natural phthalide compound that exhibits potent antioxidant, anti-inflammatory, and neuroprotective activities. It suppresses lipopolysaccharide-induced inflammatory signaling by modulating the NF-kB and MAPK pathways, leading to down-regulation of pro-inflammatory cytokines and inducible nitric oxide synthase. Additionally, ligustilide reduces oxidative stress and inhibits apoptotic cell death in vascular and neural tissues.

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.