CAS No. 1025967-78-5

Batch: Purity:99.74
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Lifitegrast Chemical Structure
Chemical Structure
Check the Lifitegrast product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-2-[[2-(1-benzofuran-6-carbonyl)-5,7-dichloro-3,4-dihydro-1H-isoquinoline-6-carbonyl]amino]-3-(3-methylsulfonylphenyl)propanoic acid
CAS Number 1025967-78-5
Molecular Formula

C29H24Cl2N2O7S
Molecular Weight (MW) 615.48
SMILES CS(=O)(=O)C1=CC=CC(=C1)CC(C(=O)O)NC(=O)C2=C(C=C3CN(CCC3=C2Cl)C(=O)C4=CC5=C(C=C4)C=CO5)Cl
InChIKey JFOZKMSJYSPYLN-QHCPKHFHSA-N

Ordering Information

Biological Activity

Lifitegrast is a small-molecule integrin antagonist that targets lymphocyte function-associated antigen-1 (LFA-1). By blocking the interaction between LFA-1 and intercellular adhesion molecule-1 (ICAM-1), Lifitegrast inhibits T cell adhesion, activation, and recruitment. This blockade suppresses downstream release of pro-inflammatory cytokines, reducing ocular surface inflammation and attenuating pathological phenotypes associated with dry eye disease. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (162.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 20 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.