CAS No. 2586-96-1
Batch:
Purity:99.03
Chemical Structure
Check the
Liensinine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol | |
|---|---|---|
| CAS Number | 2586-96-1 | |
| Molecular Formula |
C37H42N2O6 |
|
| Molecular Weight (MW) | 610.74 | |
| SMILES | CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)O)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)OC)O)OC | |
| InChIKey | XCUCMLUTCAKSOZ-FIRIVFDPSA-N |
Biological Activity
Liensinine is a natural alkaloid isolated from lotus seeds that functions as a late-stage autophagy inhibitor by blocking autophagosome-lysosome fusion. By impairing autophagic flux, it leads to autophagosome accumulation and suppresses mitophagy. Downstream, liensinine exhibits anti-proliferative, pro-apoptotic, and anti-inflammatory activities, effectively sensitizing various cancer cells to chemotherapeutic agents through the activation of apoptotic pathways. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(163.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 50 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.