CAS No. 156897-06-2

Batch: Purity:99.85
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Licofelone (ML3000) Chemical Structure
Chemical Structure
Check the Licofelone (ML3000) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid
CAS Number 156897-06-2
Molecular Formula

C23H22ClNO2
Molecular Weight (MW) 379.88
SMILES CC1(CC2=C(C(=C(N2C1)CC(=O)O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C
InChIKey UAWXGRJVZSAUSZ-UHFFFAOYSA-N

Ordering Information

Biological Activity

Licofelone (ML3000) is a potent dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) enzymes. By simultaneously targeting the COX and 5-LOX signaling pathways, Licofelone suppresses the biosynthesis of both proinflammatory prostaglandins and leukotrienes. Downstream, this dual pathway inhibition leads to decreased inflammatory responses, reduced cell viability, and the induction of apoptosis, demonstrating significant biological activity in models of osteoarthritis.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 76 mg/mL (200.06 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 10 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.