CAS No. 1883548-96-6

Batch: Purity:99.81
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Liarozole dihydrochloride Chemical Structure
Chemical Structure
Check the Liarozole dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-[(3-chlorophenyl)-imidazol-1-ylmethyl]-1H-benzimidazole;dihydrochloride
CAS Number 1883548-96-6
Molecular Formula

C₁₇H₁₅Cl₃N₄
Molecular Weight (MW) 381.69
SMILES Cl.Cl.ClC1=CC=CC(=C1)C([N]2C=CN=C2)C3=CC4=C(C=C3)N=C[NH]4
InChIKey NKDMRTVUEJWCCQ-UHFFFAOYSA-N

Ordering Information

Biological Activity

Liarozole dihydrochloride is an orally active, cytochrome P450-dependent retinoic acid metabolism-blocking agent that inhibits CYP26 (IC50 2.2–6.0 μM) and rat CYP17 (IC50 260 nM). By blocking cytochrome P450-mediated metabolism of retinoic acid and testicular androgen synthesis, it elevates endogenous retinoic acid levels and suppresses androgen production, leading to sustained retinoic acid signaling pathways and inhibition of cell proliferation in retinoic acid-sensitive biological systems.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 76 mg/mL (199.11 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 76 mg/mL
Ethanol 76 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.