CAS No. 244240-24-2
Batch:
Purity:99.98
Chemical Structure
Check the
LFM-A13
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide | |
|---|---|---|
| CAS Number | 244240-24-2 | |
| Molecular Formula |
C11H8Br2N2O2
|
|
| Molecular Weight (MW) | 360 | |
| SMILES | CC(=C(C#N)C(=O)NC1=C(C=CC(=C1)Br)Br)O | |
| InChIKey | UVSVTDVJQAJIFG-VURMDHGXSA-N |
LFM-A13 is a specific Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 2.5 μM. It exhibits greater than 100-fold selectivity for BTK over other protein kinases, including JAK1, JAK2, HCK, EGFR, and IRK. By inhibiting BTK activity, LFM-A13 disrupts B-cell receptor signaling pathways, preventing downstream activation and inducing apoptosis in leukemic cell lines. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
72 mg/mL
(200.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.