CAS No. 99291-25-5
| IUPAC Name | (2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol | |
|---|---|---|
| CAS Number | 99291-25-5 | |
| Molecular Formula |
C13H20N2O2 |
|
| Molecular Weight (MW) | 236.31 | |
| SMILES | C1CN(CCN1CC(CO)O)C2=CC=CC=C2 | |
| InChIKey | PTVWPYVOOKLBCG-ZDUSSCGKSA-N |
Levodropropizine is a peripherally acting antitussive agent and histamine receptor inhibitor with anti-allergic properties. It reduces cough by interfering with the activation of peripheral sensory nerve endings, particularly unmyelinated C-fibers, and modulating the release of sensory neuropeptides involved in the cough reflex. Through these peripheral mechanisms, levodropropizine suppresses neurogenic airway inflammation and attenuates sensory nerve-mediated cough responses.
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
47 mg/mL
(198.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 47 mg/mL |
| Water | 15 mg/mL |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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