CAS No. 130018-77-8

Batch: Purity:98.90
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Levocetirizine Chemical Structure
Chemical Structure
Check the Levocetirizine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 130018-77-8
Molecular Formula

C21H25ClN2O3
Molecular Weight (MW) 388.89
SMILES OC(=O)COCCN1CCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3

Biological Activity

Levocetirizine is a selective, third-generation peripheral histamine H1 receptor antagonist. By binding to H1 histamine receptors, it inhibits histamine-driven cellular signaling pathways and suppresses the release of pro-inflammatory cytokines and chemokines from mast cells and basophils. Consequently, levocetirizine attenuates eosinophil recruitment, decreases vascular permeability, and prevents airway hyperresponsiveness and smooth muscle contraction in experimental models of allergic inflammation.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 78 mg/mL (200.57 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 78 mg/mL
Ethanol 78 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.