CAS No. 103129-82-4

Batch: Purity:99.86
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Levamlodipine Chemical Structure
Chemical Structure
Check the Levamlodipine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-O-ethyl 5-O-methyl (4S)-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS Number 103129-82-4
Molecular Formula

C20H25ClN2O5
Molecular Weight (MW) 408.88
SMILES CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
InChIKey HTIQEAQVCYTUBX-KRWDZBQOSA-N

Ordering Information

Biological Activity

Levamlodipine is a dihydropyridine calcium channel blocker that selectively targets L-type voltage-gated calcium channels. By inhibiting trans-sarcolemmal calcium ion influx into vascular smooth muscle and cardiac muscle cells, levamlodipine disrupts calcium-dependent intracellular signaling pathways, leading to vasodilation and reduced peripheral vascular resistance. This inhibition suppresses intracellular calcium accumulation, thereby promoting the relaxation of arterial smooth muscle and modulating vascular tone. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 82 mg/mL (200.54 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 82 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.