Leuprolide Acetate

For research use only.

Catalog No.S3718 Synonyms: Leuprorelin Acetate

Leuprolide Acetate Chemical Structure

Molecular Weight(MW): 1269.45

Leuprolide acetate is a synthetic nonapeptide that is a potent gonadotropin-releasing hormone receptor (GnRHR) agonist used for diverse clinical applications, including the treatment of prostate cancer, endometriosis, uterine fibroids, central precocious puberty and in vitro fertilization techniques.

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Biological Activity

Description Leuprolide acetate is a synthetic nonapeptide that is a potent gonadotropin-releasing hormone receptor (GnRHR) agonist used for diverse clinical applications, including the treatment of prostate cancer, endometriosis, uterine fibroids, central precocious puberty and in vitro fertilization techniques.
Targets
GnRHR [1]
()
In vitro

Leuprolide acetate is a synthetic nonapeptide that is a potent gonadotropin-releasing hormone receptor (GnRHR) agonist. Leuprolide acetate suppresses gonadotrope secretion of luteinizing hormone and follicle-stimulating hormone that subsequently suppresses gonadal sex steroid production[1].

In vivo Leuprolide acetate is used for diverse clinical applications, including the treatment of prostate cancer, endometriosis, uterine fibroids, central precocious puberty and in vitro fertilization techniques. Leuprolide acetate is presently being tested for the treatment of Alzheimer's disease, polycystic ovary syndrome, functional bowel disease, short stature, premenstrual syndrome and even as an alternative for contraception. Leuprolide acetate is considered to be a very safe and tolerable drug[1].

Protocol

Cell Research:

[2]

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  • Cell lines: PC-3 cells
  • Concentrations: 10−6 M or 10−11 M
  • Incubation Time: 6, 12, 18, 24 and 30 days.
  • Method:

    The cells were seeded at a density of 25,000 cells/ml of standard culture medium in 40-mm TPP dishes. Once they adhered to the culture plates (after 24 h), the medium was renewed with DMEM supplemented with 5% charcoal-treated FBS (CH-FBS) and 10−6 M or 10−11 M Leuprolide acetate. The medium was changed every 48 h, while LA was added daily to the cultures. PC-3 cells were exposed to the analogue for 6, 12, 18, 24 and 30 days. Every six days, cells were trypsinized, seeded (25,000 cells/ml) into the 40-mm TPP dishes and, once they adhered to the culture plates, treated as described above for a further 6-day period. At the end of each treatment period, the cells were analyzed by AFM. In all the experiments, control cultures were run in parallel.


    (Only for Reference)

Solubility (25°C)

In vitro DMSO 100 mg/mL (78.77 mM)
Water 100 mg/mL (78.77 mM)
Ethanol 100 mg/mL (78.77 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 1269.45
Formula

C59H84N16O12. C2H4O2

CAS No. 74381-53-6
Storage powder
in solvent
Synonyms Leuprorelin Acetate
Smiles CCNC(=O)C1CCCN1C(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=C(O)C=C2)NC(=O)C(CO)NC(=O)C(CC3=C[NH]C4=C3C=CC=C4)NC(=O)C(CC5=C[NH]C=N5)NC(=O)C6CCC(=O)N6.CC(O)=O

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID