CAS No. 878672-00-5
Batch:
Purity:99.59
Chemical Structure
Check the
Lesinurad
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[[5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-1,2,4-triazol-3-yl]sulfanyl]acetic acid | |
|---|---|---|
| CAS Number | 878672-00-5 | |
| Molecular Formula |
C17H14BrN3O2S |
|
| Molecular Weight (MW) | 404.28 | |
| SMILES | C1CC1C2=CC=C(C3=CC=CC=C23)N4C(=NN=C4Br)SCC(=O)O | |
| InChIKey | FGQFOYHRJSUHMR-UHFFFAOYSA-N |
Lesinurad is a selective uric acid reabsorption inhibitor that targets urate transporter 1 (URAT1) and organic anion transporter 4 (OAT4). By inhibiting URAT1- and OAT4-mediated urate transport in renal proximal tubule cells, Lesinurad suppresses the tubular reabsorption of uric acid. This targeted inhibition promotes renal urate excretion and regulates urate homeostasis, lowering serum uric acid levels. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(197.88 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 54 mg/mL |
| Water | Insoluble |
| DMSO |
81 mg/mL
(200.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.