CAS No. 143257-98-1
Batch:
Purity:99.20
Chemical Structure
Check the
Lerisetron
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 143257-98-1 | |
|---|---|---|
| Molecular Formula |
C18H20N4 |
|
| Molecular Weight (MW) | 292.38 | |
| SMILES | C1CN(CCN1)C2=NC3=CC=CC=C3N2CC4=CC=CC=C4 |
Biological Activity
Lerisetron is a potent 5-HT3 receptor antagonist that selectively binds and blocks serotonin 5-HT3 receptors. By inhibiting 5-HT3 receptor activation, lerisetron prevents serotonin-induced depolarization of primary vagal afferent nerves and central nervous system neurons. This antagonist activity disrupts ligand-gated ion channel signaling, suppressing emetic reflex responses and modulating gastrointestinal motility in preclinical functional models. [1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
58 mg/mL
(198.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 58 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
Jump to
Note: Technical data last updated: Sep 1, 2026.