CAS No. 132866-11-6

Batch: Purity:99.98
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Lercanidipine hydrochloride Chemical Structure
Chemical Structure
Check the Lercanidipine hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;hydrochloride
CAS Number 132866-11-6
Molecular Formula

C36H41N3O6.HCl
Molecular Weight (MW) 648.19
SMILES CC1=C(C(C(=C(N1)C)C(=O)OC(C)(C)CN(C)CCC(C2=CC=CC=C2)C3=CC=CC=C3)C4=CC(=CC=C4)[N+](=O)[O-])C(=O)OC.Cl
InChIKey WMFYOYKPJLRMJI-UHFFFAOYSA-N

Ordering Information

Biological Activity

Lercanidipine hydrochloride is a dihydropyridine calcium channel blocker that selectively targets L-type voltage-gated calcium channels. By blocking transmembrane calcium influx into vascular smooth muscle cells, this compound inhibits calcium-dependent intracellular signaling pathways and prevents intracellular calcium accumulation. Consequently, it suppresses vascular smooth muscle contraction and induces sustained vasodilation in vascular tissues.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 66 mg/mL (101.82 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 1 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.