CAS No. 2007885-39-2
Batch:
Purity:98.79
Chemical Structure
Check the
Lenumlostat
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | [3-[[4-(aminomethyl)-6-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]-[(3R,4R)-3-fluoro-4-hydroxypyrrolidin-1-yl]methanone | |
|---|---|---|
| CAS Number | 2007885-39-2 | |
| Molecular Formula |
C18H17F4N3O3 |
|
| Molecular Weight (MW) | 399.34 | |
| InChIKey | ODGXXYXJORZPHE-ZIAGYGMSSA-N |
Lenumlostat is a potent, selective, and orally bioavailable inhibitor of lysyl oxidase-like 2 (LOXL2). By directly inhibiting LOXL2 activity, it blocks extracellular matrix remodeling and suppresses collagen cross-linking within fibrotic tissues. This disruption of matrix stiffening leads to downstream attenuation of pro-fibrotic signaling and reduction of fibrotic tissue accumulation, exhibiting marked anti-fibrotic activity across preclinical disease models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
80 mg/mL
(200.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 80 mg/mL |
| Water | 2 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.