CAS No. 1354690-24-6

Batch: Purity:99.47
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leniolisib (CDZ 173) Chemical Structure
Chemical Structure
Check the leniolisib (CDZ 173) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 1-[(3S)-3-[[6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]pyrrolidin-1-yl]propan-1-one
CAS Number 1354690-24-6
Molecular Formula

C21H25F3N6O2
Molecular Weight (MW) 450.46
SMILES CCC(=O)N1CCC(C1)NC2=NC=NC3=C2CN(CC3)C4=CC(=C(N=C4)OC)C(F)(F)F
InChIKey MWKYMZXCGYXLPL-ZDUSSCGKSA-N

Ordering Information

Biological Activity

Leniolisib (CDZ 173) is a potent and isoform-selective PI3K inhibitor that exhibits high selectivity for PI3Kδ over PI3Kα, PI3Kβ, and PI3Kγ. Targeted inhibition of PI3Kδ blocks downstream AKT pathway signaling, leading to reduced cellular proliferation and impaired function of activated immune cell lineages. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 90 mg/mL (199.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 13 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.