CAS No. 1350636-82-6

Batch: Purity:98.98
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Lefamulin acetate (Xenleta) Chemical Structure
Chemical Structure
Check the Lefamulin acetate (Xenleta) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name acetic acid;[(1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]sulfanylacetate
CAS Number 1350636-82-6
Molecular Formula

C30H49NO7S
Molecular Weight (MW) 567.78
SMILES CC1CCC23CCC(=O)C2C1(C)C(CC(C)(C=C)C(O)C3C)OC(=O)CSC4CCC(N)CC4O.CC(O)=O
InChIKey WSMXIQXWHPSVDE-ZPJPNJFZSA-N

Ordering Information

Biological Activity

Lefamulin acetate is a pleuromutilin antibiotic that inhibits bacterial protein synthesis by targeting the peptidyl transferase center of the 50S bacterial ribosome. By binding to the peptidyl transferase center, it prevents proper transfer RNA positioning required for peptide chain elongation. This mechanism blocks bacterial translation and suppresses microbial growth in respiratory pathogens. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (176.12 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.