CAS No. 312946-37-5
Batch:
Purity:97.50
Chemical Structure
Check the
LDN-27219
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-(4-oxo-3,5-diphenylthieno[2,3-d]pyrimidin-2-yl)sulfanylacetohydrazide | |
|---|---|---|
| CAS Number | 312946-37-5 | |
| Molecular Formula |
C₂₀H₁₆N₄O₂S₂ |
|
| Molecular Weight (MW) | 408.5 | |
| InChIKey | WLBUICQBNZXIDJ-UHFFFAOYSA-N |
LDN-27219 is a potent, reversible, and slow-binding inhibitor of tissue transglutaminase (TGase) that targets the GTP-binding regulatory site rather than the catalytic active site. By stabilizing TGase in its closed conformation and inhibiting transamidase activity, LDN-27219 promotes nitric oxide- and potassium channel-dependent vasorelaxation, leading to age-dependent blood pressure reduction and improved endothelium-dependent vasodilation in resistance arteries. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
82 mg/mL
(200.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
82 mg/mL
(200.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.