CAS No. 2304621-06-3
Batch:
Purity:99.45
Chemical Structure
Check the
LDC203974 (IMT1B)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (3S)-1-[(2R)-2-[4-(2-chloro-4-fluorophenyl)-2-oxochromen-7-yl]oxypropanoyl]piperidine-3-carboxylic acid | |
|---|---|---|
| CAS Number | 2304621-06-3 | |
| Molecular Formula |
C24H21ClFNO6 |
|
| Molecular Weight (MW) | 473.88 | |
| InChIKey | PFEKWBKJUBCXDT-KGLIPLIRSA-N |
LDC203974 (IMT1B) is an orally active, noncompetitive, and specific allosteric inhibitor of human mitochondrial RNA polymerase (POLRMT). Pharmacological targeting of POLRMT disrupts mitochondrial DNA (mtDNA) transcription and suppresses the expression of essential respiratory chain subunits. This impairs the function of the oxidative phosphorylation (OXPHOS) complex, leading to cellular energy depletion and exerting robust antitumor effects. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
95 mg/mL
(200.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 95 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.