CAS No. 2304621-31-4
Batch:
Purity:99.32
Chemical Structure
Check the
LDC195943 (IMT1)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N,N-dimethyl-2-[4-(2-methylphenyl)-2-oxochromen-7-yl]oxypropanamide | |
|---|---|---|
| CAS Number | 2304621-31-4 | |
| Molecular Formula |
C21H21NO4 |
|
| Molecular Weight (MW) | 351.4 | |
| InChIKey | DBIPGWVTQBAHGP-UHFFFAOYSA-N |
LDC195943 (IMT1) is a specific and noncompetitive allosteric inhibitor of human mitochondrial RNA polymerase (POLRMT). By inducing a conformational change in POLRMT, IMT1 blocks substrate binding and inhibits mitochondrial DNA transcription in a dose-dependent manner. This disruption impairs the oxidative phosphorylation (OXPHOS) system, depletes deoxynucleoside triphosphates and citric acid cycle intermediates, and suppresses tumor cell proliferation. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(199.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 23 mg/mL |
| Water | Insoluble |
| DMSO |
70 mg/mL
(199.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 18 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.