CAS No. 2502156-03-6
Batch:
Purity:99.58
Chemical Structure
Check the
LC-2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S,4R)-1-[(2S)-2-[3-[3-[(2S)-2-[[7-(8-chloronaphthalen-1-yl)-4-[(3S)-3-(cyanomethyl)-4-(2-fluoroprop-2-enoyl)piperazin-1-yl]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]oxymethyl]pyrrolidin-1-yl]propoxy]propanoylamino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide | |
|---|---|---|
| CAS Number | 2502156-03-6 | |
| Molecular Formula |
C59H71ClFN11O7S |
|
| Molecular Weight (MW) | 1132.78 | |
| InChIKey | ZCGQZLKPUVGCBQ-HLMPTVQRSA-N |
LC-2 is a first-in-class PROTAC degrader targeting endogenous KRAS G12C with DC50 values ranging from 0.25 μM to 0.76 μM. The molecule utilizes an MRTX849 warhead to covalently engage KRAS G12C and recruits the VHL E3 ubiquitin ligase, promoting rapid and sustained ubiquitination and proteasomal degradation of the mutant protein. This targeted degradation effectively suppresses downstream MAPK signaling in KRAS G12C-mutant cancer cells.
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(88.27 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.