CAS No. 226929-39-1
| IUPAC Name | [1-[[3-[(4-bromophenyl)methyl]imidazol-4-yl]methyl]-4-naphthalen-1-ylpyrrol-3-yl]-morpholin-4-ylmethanone | |
|---|---|---|
| CAS Number | 226929-39-1 | |
| Molecular Formula |
C30H27BrN4O2 |
|
| Molecular Weight (MW) | 555.46 | |
| SMILES | C1COCCN1C(=O)C2=CN(C=C2C3=CC=CC4=CC=CC=C43)CC5=CN=CN5CC6=CC=C(C=C6)Br | |
| InChIKey | GUUIRIMAQGOLHT-UHFFFAOYSA-N |
LB42708 is an orally active farnesyltransferase inhibitor that selectively blocks the farnesylation of H-Ras, N-Ras, and K-Ras. By inhibiting farnesyltransferase, it prevents the post-translational prenylation and plasma membrane localization of Ras proteins. This inhibition suppresses downstream Ras/Raf/MEK/ERK and PI3K/AKT signaling pathways, resulting in the inhibition of cell proliferation and induction of apoptosis in Ras-dependent cancer cells. [1]
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Concentration
Volume
Mass
|
|---|
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(180.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 86 mg/mL |
| Water | Insoluble |
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
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