CAS No. 190791-29-8
Batch:
Purity:99.97
Chemical Structure
Check the
Lasofoxifene Tartrate
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 190791-29-8 | |
|---|---|---|
| Molecular Formula |
C32H37NO8 |
|
| Molecular Weight (MW) | 563.64 | |
| SMILES | C1CCN(C1)CCOC2=CC=C(C=C2)C3C(CCC4=C3C=CC(=C4)O)C5=CC=CC=C5.C(C(C(=O)O)O)(C(=O)O)O |
Lasofoxifene Tartrate is a third-generation non-steroidal selective estrogen receptor modulator (SERM) that binds with high affinity to human estrogen receptor-α (ERα). By selectively binding ERα, it modulates estrogen receptor-mediated transcriptional activity and signaling pathways. Downstream, this targeted action alters estrogen-responsive gene expression, resulting in suppressed bone resorption and reduced serum cholesterol levels in preclinical models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(177.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.