CAS No. 927961-18-0

Batch: Purity:99.59
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Lanifibranor (IVA-337) Chemical Structure
Chemical Structure
Check the Lanifibranor (IVA-337) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloroindol-2-yl]butanoic acid
CAS Number 927961-18-0
Molecular Formula

C19H15ClN2O4S2
Molecular Weight (MW) 434.92
SMILES C1=CC2=C(C=C1S(=O)(=O)N3C4=C(C=C(C=C4)Cl)C=C3CCCC(=O)O)SC=N2
InChIKey OQDQIFQRNZIEEJ-UHFFFAOYSA-N

Ordering Information

Biological Activity

Lanifibranor (IVA-337) is a pan-peroxisome proliferator-activated receptor (PPAR) agonist that activates hPPARα (EC50 1537 nM), hPPARδ (EC50 866 nM), and hPPARγ (EC50 206 nM). By activating all three PPAR isoforms, it regulates gene expression involved in lipid metabolism, inflammation, and tissue remodeling. This balanced activation inhibits pro-fibrotic signaling pathways, reduces collagen synthesis, and exerts potent anti-inflammatory and anti-fibrotic effects in preclinical models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 87 mg/mL (200.03 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.