CAS No. 144481-98-1

Batch: Purity:99.99
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Landiolol hydrochloride Chemical Structure
Chemical Structure
Check the Landiolol hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 144481-98-1
Molecular Formula

C25H39N3O8.HCl
Molecular Weight (MW) 546.05
SMILES CC1(OCC(O1)COC(=O)CCC2=CC=C(C=C2)OCC(CNCCNC(=O)N3CCOCC3)O)C.Cl

Biological Activity

Landiolol hydrochloride is an ultra-short-acting, highly selective β1-adrenoceptor antagonist. By selectively binding to and inhibiting β1-adrenergic receptors, it blocks catecholamine-mediated activation of Gs protein-coupled receptor signaling and inhibits adenylate cyclase. The subsequent reduction in intracellular cyclic AMP (cAMP) levels suppresses sympathetic signaling in cardiomyocytes, leading to attenuated heart rate and cardiac contractile responses without significantly affecting vascular β2-adrenoceptors. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (183.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 42 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Iguchi S, et al. Chem Pharm Bull (Tokyo). 1992;40(6):1462-9.

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Note: Technical data last updated: Sep 1, 2026.