Lamotrigine-13C,d3 CAS Number

Lamotrigine-13C,d3 is an isotope-labeled compound functioning as a stable isotope derivative of lamotrigine, an anticonvulsant agent that acts as a voltage-gated sodium channel blocker. By stabilizing presynaptic neuronal membranes and inhibiting voltage-gated sodium channels, it suppresses the excessive release of excitatory neurotransmitters such as glutamate, thereby reducing sustained repetitive high-frequency neuronal firing and dampening excitatory synaptic transmission in central nervous system pathways. ^[1]

[1] Leach MJ, et al. Epilepsia. 1986;27(5):490-7.