Clinical Trials

Lamivudine has been evaluated in numerous clinical trials spanning Early Phase 1 through Phase 4, primarily focusing on HIV-1, HIV-2, chronic hepatitis B, and complications such as hepatocellular carcinoma and tuberculosis co-infection. Sponsored by academic institutions, government bodies like NIAID, and pharmaceutical companies such as Merck Sharp & Dohme, these studies cover recruitment statuses ranging from active and completed to terminated or withdrawn. Recent protocols also investigate novel indications, including intra-ocular applications for retinal detachment.

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT07393659 RECRUITING
HIV Infections
ViiV Healthcare
2026-07-21 PHASE3
NCT07792096 NOT_YET_RECRUITING
HIV Infection
University College, London
2026-11 PHASE3
NCT06428045 RECRUITING
High Grade Glioma
University of Miami
2025-04-15 PHASE1
NCT04375800 RECRUITING
Human Immunodeficiency Virus (HIV) Infection
Merck Sharp & Dohme LLC
2021-02-03 PHASE2
NCT06356740 NOT_YET_RECRUITING
Systemic Lupus Erythematosus
Hospices Civils de Lyon
2024-09-01 PHASE2
NCT07631897 NOT_YET_RECRUITING
HIV; Art Therapy; TB - Tuberculosis
Shanghai Public Health Clinical Center
2026-06 PHASE4
NCT06497465 RECRUITING
Tuberculosis; HIV
Johns Hopkins University
2025-09-18 PHASE3
NCT06203132 RECRUITING
HIV-1-infection
ANRS, Emerging Infectious Diseases
2025-01-27 PHASE3
NCT07673965 NOT_YET_RECRUITING
HIV (Human Immunodeficiency Virus); Sleep
University of Witwatersrand, South Africa
2026-08-20 PHASE4
NCT04696575 RECRUITING
Extensive Stage Lung Small Cell Carcinoma
Roswell Park Cancer Institute
2021-07-02 PHASE2
NCT05373758 RECRUITING
HIV Infections; AIDS; Virologic Failure
Massachusetts General Hospital
2024-02-07
NCT07058974 ACTIVE_NOT_RECRUITING
Smokers; Former Smokers
Icahn School of Medicine at Mount Sinai
2025-08-12 PHASE1
NCT07202546 RECRUITING
HIV Infections
ViiV Healthcare
2026-02-11 PHASE2
NCT07640503 ENROLLING_BY_INVITATION
Rett Syndrome
Maria Denise Fernandes Carvalho de Andrade
2025-11-05 PHASE2
NCT06774872 RECRUITING
HIV-1-infection
Centre de Recherches et d'Etude sur la Pathologie Tropicale et le Sida
2025-04-30 PHASE2
NCT07031063 RECRUITING
HIV Infection; Metabolic Syndrome; Antiretroviral Treatment
Instituto Mexicano del Seguro Social
2025-04-01 PHASE4
NCT06967753 RECRUITING
HIV; HIV-1
UBATEC
2025-07-31 PHASE4
NCT06494579 ACTIVE_NOT_RECRUITING
Relapsed/Refractory Solid Tumors
Thomas Marron
2024-09-26 PHASE1; PHASE2
NCT07678268 RECRUITING
HIV Infection; Antiretroviral Therapy; Lentivirus Infections
Instituto Mexicano del Seguro Social
2025-07-10 PHASE4
NCT06485154 RECRUITING
HIV Prevention
University of Witwatersrand, South Africa
2024-06-01 PHASE4
NCT07075146 RECRUITING
HIV - Human Immunodeficiency Virus; Obesity; Overweight and/or Obesity
José Antonio Mata Marín
2025-05-05 PHASE3
NCT06580873 NOT_YET_RECRUITING
HIV-1-infection; Opioid Use Disorder
Saskatchewan Health Authority - Regina Area
2024-09-30 PHASE4
NCT05979311 ACTIVE_NOT_RECRUITING
HIV; HIV Infections
ViiV Healthcare
2024-02-21 PHASE3
NCT06034938 RECRUITING
Hiv
University Hospital, Caen
2024-02-08 PHASE2
NCT06907056 RECRUITING
HIV Infection
José Antonio Mata Marín
2023-11-09 PHASE4
NCT07006246 ACTIVE_NOT_RECRUITING
HIV Infection
Professor Francois Venter
2023-05-19 PHASE4
NCT06602622 RECRUITING
HIV; HIV Associate Weight Loss; HIV-1 Infection; Integrase Inhibitors, HIV; HIV PROTEASE INHIB; Weight Change; Weight Loss
Instituto Mexicano del Seguro Social
2024-08-14 PHASE4
NCT06138600 UNKNOWN
HIV Infections
University of Witwatersrand, South Africa
2023-11-01 PHASE3
NCT04337450 ACTIVE_NOT_RECRUITING
HIV Infections
PENTA Foundation
2022-04-22 PHASE2; PHASE3
NCT05917509 COMPLETED
HIV Infections
ViiV Healthcare
2023-07-06 PHASE3
NCT06519357 ACTIVE_NOT_RECRUITING
Mild Cognitive Impairment
Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
2024-10-28 PHASE2
NCT05493969 UNKNOWN
Acquired Immunodeficiency Syndrome
Shanghai Public Health Clinical Center
2022-08 PHASE4
NCT05193994 TERMINATED
Amyotrophic Lateral Sclerosis
Macquarie University, Australia
2022-02-24 PHASE3
NCT06658977 TERMINATED
Amyotrophic Lateral Sclerosis; ALS
Macquarie University, Australia
2024-11-15 PHASE3
NCT04022967 UNKNOWN
HIV-1-infection
ANRS, Emerging Infectious Diseases
2020-09-21 PHASE3
NCT06056596 TERMINATED
Retinal Detachment; Rhegmatogenous Retinal Detachment
University of Wisconsin, Madison
2024-01-30 EARLY_PHASE1
NCT06811246 COMPLETED
Healthy
Merck Sharp & Dohme LLC
2024-02-07 PHASE1
NCT04665375 TERMINATED
Hiv; Weight Gain
University Health Network, Toronto
2021-04-26 PHASE4
NCT04731103 COMPLETED
Aicardi-Goutières Syndrome
University of Edinburgh
2022-08-24 PHASE2
NCT06056596 Recruiting
Retinal Detachment|Rhegmatogenous Retinal Detachment
University of Wisconsin Madison
2024-01-30 Early Phase 1
NCT04904406 COMPLETED
Hiv; HIV Infections; HIV Cardiomyopathy; Weight Change, Body; HIV Lipodystrophy; Cardiovascular Diseases
Thomas Benfield
2020-10-22 PHASE4
NCT04826562 UNKNOWN
Human Immunodeficiency Virus
Saint Michael's Medical Center
2021-09-26 PHASE4
NCT04429152 UNKNOWN
HIV-1-infection
Professor Francois Venter
2021-02-09 PHASE3
NCT04808973 COMPLETED
HIV Infections; Pregnancy Related; Mother to Child Transmission
Fundação Bahiana de Infectologia
2021-07-01 PHASE3
NCT04585737 COMPLETED
HIV I Infection
Charlotte-Paige Rolle, MD
2020-10-05 PHASE4
NCT04880785 COMPLETED
HIV Infections
Fundacion SEIMC-GESIDA
2021-07-28 PHASE2
NCT04979468 UNKNOWN
HIV-1-infection
Societa' Italiana Di Malattie Infettive E Tropicali
2021-03-23 PHASE3
NCT04034862 COMPLETED
HIV Infections
University of Liege
2019-10-01 PHASE3
NCT04903847 UNKNOWN
Hiv; HIV Infections; HIV Lipodystrophy; Osteoporosis; Renal Insufficiency; Weight Gain; Obesity
Thomas Benfield
2021-02-02 PHASE4
NCT07014189 COMPLETED
HIV Infection; Antiretroviral Treatment; Maintenance Therapy
Cantonal Hospital of St. Gallen
2019-04-12 PHASE4
NCT04900038 TERMINATED
HIV Infections
ViiV Healthcare
2021-08-18 PHASE2
NCT04871113 COMPLETED
HIV Infections
ViiV Healthcare
2021-06-22 PHASE2
NCT04283656 COMPLETED
Transgender Health; Gender Dysphoria; Transgender Women; Human Immunodeficiency Virus
Thomas Jefferson University
2022-01-04 PHASE1
NCT03870438 COMPLETED
HIV-1
ANRS, Emerging Infectious Diseases
2019-12-14 PHASE3
NCT00799864 COMPLETED
HIV-1
Janssen Sciences Ireland UC
2011-01 PHASE2
NCT05295394 WITHDRAWN
HIV-1 Infection
Pedro Cahn
2019-05-22 PHASE4
NCT04233372 COMPLETED
Hiv
Hospital Clinic of Barcelona
2020-08-27 PHASE4
NCT04051970 TERMINATED
HIV-1-infection
ANRS, Emerging Infectious Diseases
2019-11-27 PHASE3
NCT03991013 COMPLETED
HIV Infections
University of Cape Town
2019-08-08 PHASE2
NCT03869944 UNKNOWN
HIV-1
ANRS, Emerging Infectious Diseases
2019-12-04 PHASE2
NCT04311944 UNKNOWN
HIV-1-infection
Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic
2020-09-01
NCT03760458 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2020-09-09 PHASE1; PHASE2
NCT03682848 COMPLETED
HIV Infections
ViiV Healthcare
2019-05-06 PHASE3
NCT02712801 COMPLETED
HIV/AIDS and Infections
National Center for Women and Children's Health, China CDC
2016-04 PHASE4
NCT01936233 UNKNOWN
Hepatocellular Carcinoma; Recurrence
Fudan University
2013-08 PHASE3
NCT04302896 COMPLETED
Medication Adherence; HIV
Rhonda Brand
2020-08-31 EARLY_PHASE1
NCT02659761 TERMINATED
Human Immunodeficiency Virus
University College Dublin
2016-11 PHASE4
NCT05030025 COMPLETED
HIV-1-infection
Mylan Inc.
2021-08-01 EARLY_PHASE1
NCT04827134 COMPLETED
HIV Infections
ViiV Healthcare
2021-05-07 PHASE1
NCT04385719 COMPLETED
Ebola; HIV/AIDS
Makerere University
2021-05-05 PHASE2
NCT03563742 TERMINATED
Human Immunodeficiency Virus Infections
Janssen Research & Development, LLC
2018-09-24 PHASE3
NCT03539224 UNKNOWN
HIV-1-infection
Instituto de Investigación Hospital Universitario La Paz
2017-11-02 PHASE2
NCT04021290 COMPLETED
HIV Infections
ViiV Healthcare
2019-11-11 PHASE3
NCT03311945 COMPLETED
HIV Infections; HIV-1-infection; HIV Seropositivity
Judit Pich
2018-05-02 PHASE3
NCT03272347 COMPLETED
HIV-1 Infection
Merck Sharp & Dohme LLC
2017-11-27 PHASE2
NCT02369406 ACTIVE_NOT_RECRUITING
HIV; Pediatric AIDS
Harvard School of Public Health (HSPH)
2015-05-04 PHASE2; PHASE3
NCT04424264 COMPLETED
HIV-1-infection; Tuberculosis
Professor Francois Venter
2019-12-05 PHASE1
NCT03988452 UNKNOWN
Human Immunodeficiency Virus
Makerere University
2019-07-30 PHASE3
NCT03332095 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2018-07-02 PHASE1; PHASE2
NCT03333083 TERMINATED
HIV Seropositivity; HIV Infections; HIV-1-infection
Judit Pich
2018-05-03 PHASE3
NCT03394196 TERMINATED
HIV-2 Infection
University of Washington
2018-07-04
NCT03360682 COMPLETED
HIV-1-infection; Solid Organ Transplant
Fundacion Clinic per a la Recerca Biomédica
2018-04-13 PHASE4
NCT03405194 WITHDRAWN
HIV/AIDS
Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic
2018-05-01
NCT02431975 COMPLETED
HIV
Columbia University
2015-08 PHASE4
NCT03945981 COMPLETED
HIV Infections
ViiV Healthcare
2019-07-02 PHASE3
NCT03144804 COMPLETED
Colorectal Cancer Metastatic
Massachusetts General Hospital
2017-10-31 PHASE2
NCT02384395 COMPLETED
HIV; Acute HIV Infection
University of North Carolina, Chapel Hill
2015-09
NCT04133012 Completed
HIV-1 Infection
ANRS Emerging Infectious Diseases|ViiV Healthcare
2020-02-10 Not Applicable
NCT02263079 COMPLETED
Pediatric Immuno-Tolerant Chronic Hepatitis B
Hoffmann-La Roche
2014-06-16 PHASE3
NCT04054089 COMPLETED
HIV Infections
Cristina Mussini
2020-01-23 PHASE4
NCT01491295 UNKNOWN
Chronic Hepatitis B
Taipei Veterans General Hospital, Taiwan
2012-09 PHASE4
NCT03836833 UNKNOWN
HIV
Drugs for Neglected Diseases
2019-06-04 PHASE1; PHASE2
NCT03033836 COMPLETED
HIV Infections
Fundación Huésped
2015-12 PHASE4
NCT02945163 COMPLETED
HIV Infections
Shanghai Public Health Clinical Center
2018-03-05 PHASE4
NCT03446573 COMPLETED
HIV Infections
ViiV Healthcare
2018-01-18 PHASE3
NCT02150993 COMPLETED
HIV-2 Infection
ANRS, Emerging Infectious Diseases
2016-01-26 PHASE2; PHASE3
NCT03067285 COMPLETED
HIV Infections
Fundacion SEIMC-GESIDA
2017-09-08 PHASE4
NCT00872872 COMPLETED
NVP Plasma Level; NVP Related Mutation; 3TC Related Mutation
Thai Red Cross AIDS Research Centre
2008-05
NCT03595709 COMPLETED
HIV Infections
Yu-Jay Corp.
2018-12-06 PHASE3
NCT01618305 COMPLETED
HIV Infections
Westat
2013-09-05 PHASE4
NCT02629822 COMPLETED
HIV-1 Infection
Merck Sharp & Dohme LLC
2016-01-14 PHASE2
NCT02273765 COMPLETED
HIV-1 Infection; Tuberculosis
ANRS, Emerging Infectious Diseases
2015-09-11 PHASE3
NCT02652793 COMPLETED
Human Immunodeficiency Virus
Judit Pich
2015-11
NCT03205566 COMPLETED
Hiv
Guy's and St Thomas' NHS Foundation Trust
2017-09-19 PHASE4
NCT02652260 COMPLETED
HIV-1; Central Nervous System
Merck Sharp & Dohme LLC
2016-03-04 PHASE2
NCT02777229 COMPLETED
HIV-1 Infection
ANRS, Emerging Infectious Diseases
2016-07 PHASE3
NCT03223402 COMPLETED
HIV Infections
Cantonal Hospital of St. Gallen
2016-12-23
NCT01125696 COMPLETED
HIV; Hepatitis B
Centers for Disease Control and Prevention
2012-05 PHASE2
NCT03441984 COMPLETED
HIV Infections
ViiV Healthcare
2018-02-26 PHASE1
NCT02831764 COMPLETED
Infection, Human Immunodeficiency Virus; HIV Infections
ViiV Healthcare
2016-07-18 PHASE3
NCT02369965 COMPLETED
HIV Infections; AIDS
Frontier Biotechnologies Inc.
2014-02-19 PHASE3
NCT03236584 UNKNOWN
Proportion of Patients With a Sustained Virological Response (Serum HBV DNA <20 IU/mL) at Week 48
Uijeongbu St. Mary Hospital
2015-09-01 PHASE3
NCT02397096 COMPLETED
HIV-1 Infection
Merck Sharp & Dohme LLC
2015-06-09 PHASE3
NCT02363452 COMPLETED
Aicardi-Goutières Syndrome (AGS)
Assistance Publique - Hôpitaux de Paris
2015-09-10 PHASE2
NCT01900106 COMPLETED
HIV Infection
University of Modena and Reggio Emilia
2013-11 PHASE3
NCT02499874 COMPLETED
HIV
St Stephens Aids Trust
2015-08 PHASE1
NCT03078556 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
2017-03-27 PHASE1
NCT01528865 WITHDRAWN
Lymphoma
University of Michigan Rogel Cancer Center
2015-12 PHASE1; PHASE2
NCT02470650 WITHDRAWN
Patient Compliance; Antiretroviral Therapy Intolerance
Juan A. Arnaiz
2015-06 PHASE4
NCT02263326 COMPLETED
HIV Infection
Babafemi Taiwo
2014-12 PHASE3
NCT02770508 COMPLETED
HIV-1 Infection
Fundación Huésped
2015-11 PHASE4
NCT02596334 TERMINATED
HIV
Centre Hospitalier Régional d'Orléans
2015-12-23 PHASE3
NCT02605954 COMPLETED
HIV-1 Infection
Gilead Sciences
2015-11-18 PHASE3
NCT01580202 COMPLETED
Malignancy; Hepatitis B
Seoul National University Hospital
2012-04 PHASE3
NCT02603107 COMPLETED
HIV-1 Infection
Gilead Sciences
2015-11-20 PHASE3
NCT02607930 COMPLETED
HIV-1 Infection
Gilead Sciences
2015-11-13 PHASE3
NCT02403674 COMPLETED
Human Immunodeficiency Virus (HIV)
Merck Sharp & Dohme LLC
2015-06-05 PHASE3
NCT02827643 UNKNOWN
Bone Density
Mahidol University
2016-06
NCT02527096 COMPLETED
HIV-1 Infection
ANRS, Emerging Infectious Diseases
2015-09-17 PHASE2
NCT02284035 COMPLETED
AIDS
Juan A. Arnaiz
2015-09-27 PHASE3
NCT02582684 COMPLETED
HIV-1 Infection
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
2015-12-08 PHASE2
NCT02509195 COMPLETED
HIV
St Stephens Aids Trust
2015-08-04 PHASE4
NCT02482272 UNKNOWN
Hepatitis B, Chronic
Asan Medical Center
2015-05 PHASE4
NCT00810524 UNKNOWN
Hepatitis B, Chronic
Sun Yat-sen University
2007-01 PHASE4
NCT02447705 COMPLETED
Disorder Related to Transplantation; Virus Diseases; Injury Due to Exposure to External Cause
Chang Gung Memorial Hospital
2013-06 PHASE2; PHASE3
NCT02632474 COMPLETED
HIV Infections
Shanghai Public Health Clinical Center
2015-04 PHASE4
NCT02566707 TERMINATED
HIV-1 Infection
Radboud University Medical Center
2015-08 PHASE2
NCT03178084 COMPLETED
HIV/AIDS
Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
2014-10-15 PHASE3
NCT02893488 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
2016-09-01 PHASE1
NCT01061151 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2011-03-01 PHASE3
NCT02560649 UNKNOWN
Chronic Hepatitis B
Ruijin Hospital
2015-05 PHASE4
NCT02219672 UNKNOWN
AIDS/HIV PROBLEM
Peking Union Medical College
2014-07 PHASE3
NCT02738931 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
2016-05 PHASE1
NCT02159599 COMPLETED
HIV Infection
Fundacion SEIMC-GESIDA
2014-07 PHASE4
NCT01599364 COMPLETED
Human Immunodeficiency Virus
Catholic University of the Sacred Heart
2014-04 PHASE4
NCT01627223 TERMINATED
Chronic Hepatitis B
Taichung Veterans General Hospital
2012-07 PHASE4
NCT01905059 COMPLETED
HIV Infection
ANRS, Emerging Infectious Diseases
2014-02 PHASE3
NCT02634073 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
2016-01-01 PHASE4
NCT02211482 COMPLETED
HIV-1 Infection
Fundación Huésped
2014-10 PHASE4
NCT01732367 COMPLETED
Chronic Hepatitis B
Keimyung University Dongsan Medical Center
2012-11 PHASE4
NCT02246998 COMPLETED
HIV-1 Infection
Gilead Sciences
2014-12-15 PHASE4
NCT02067767 COMPLETED
HIV-1 Infection
Nantes University Hospital
2014-02 PHASE2
NCT01914744 UNKNOWN
Non-Hodgkin Lymphoma; Hepatitis B Reactivation
Fudan University
2013-02 PHASE2
NCT02539576 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
2015-10 PHASE1
NCT01844297 UNKNOWN
AIDS/HIV PROBLEM
Peking Union Medical College
2013-05
NCT01910402 COMPLETED
Infection, Human Immunodeficiency Virus; HIV Infections
ViiV Healthcare
2013-08-22 PHASE3
NCT02120352 COMPLETED
Infection, Human Immunodeficiency Virus; HIV Infections
ViiV Healthcare
2014-04-28 PHASE2
NCT01894269 UNKNOWN
Hepatocellular Carcinoma
Sun Yat-sen University
2013-07 PHASE4
NCT01656122 COMPLETED
HIV
The HIV Netherlands Australia Thailand Research Collaboration
2012-07 PHASE2; PHASE3
NCT01511237 COMPLETED
HIV Infections
Institut de Recherche pour le Developpement
2011-12 PHASE3
NCT02337127 UNKNOWN
Chronic Hepatitis B
Kaohsiung Medical University Chung-Ho Memorial Hospital
2011-06 PHASE4
NCT00074581 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2005-02 PHASE3
NCT02105987 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
2014-04 PHASE3
NCT02670772 COMPLETED
Acquired Immune Deficiency Syndrome; Human Immunodeficiency Virus
Willem Daniel Francois Venter
2012-07 PHASE3
NCT01387022 COMPLETED
Antiretroviral Treatment Outcomes
Centre for the AIDS Programme of Research in South Africa
2011-06
NCT01352715 COMPLETED
HIV-1 Infection
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
2012-03-13 PHASE3
NCT02894554 TERMINATED
HBsAg-positive Renal Allograft Recipients
National Taiwan University Hospital
2014-07 PHASE4
NCT00823550 UNKNOWN
Hepatitis B, Chronic
Yonsei University
2009-01 PHASE4
NCT01340950 COMPLETED
HIV Infections; Central Nervous System Diseases; Dementia
University of California, San Diego
2010-07 PHASE4
NCT01471821 COMPLETED
HIV Infection
Juan A. Arnaiz
2011-10 PHASE4
NCT01693679 UNKNOWN
HBV-related Liver Cirrhosis
Shao-quan Zhang
2012-09 PHASE4
NCT01307488 COMPLETED
HIV Infection
Fundacion SEIMC-GESIDA
2011-09 PHASE4
NCT02202473 COMPLETED
Chronic Hepatitis B
Southeast University, China
PHASE4
NCT02604004 COMPLETED
HIV INFECTIONS
Universidade Federal de Pernambuco
2013-04 PHASE1
NCT01641809 COMPLETED
Infection, Human Immunodeficiency Virus; HIV Infections
ViiV Healthcare
2012-08-06 PHASE2
NCT01354652 TERMINATED
Lactic Acidosis
Asan Medical Center
2011-05 PHASE4
NCT00719602 COMPLETED
HIV Infections; Malaria
International Maternal Pediatric Adolescent AIDS Clinical Trials Group
2009-08 EARLY_PHASE1
NCT01565889 COMPLETED
Hepatitis C; HIV
Gilead Sciences
2012-03 PHASE1; PHASE2
NCT00993031 COMPLETED
Malaria; HIV Infections
University of California, San Francisco
2009-12-15 PHASE3
NCT01743079 COMPLETED
Chronic Hepatitis B; Late Pregnancy; Transmission; Complication
Beijing YouAn Hospital
2009-01 PHASE4
NCT01751555 COMPLETED
Hiv
National Center for AIDS/STD Control and Prevention, China CDC
2011-02 PHASE4
NCT01160120 COMPLETED
HIV
The HIV Netherlands Australia Thailand Research Collaboration
2010-06 PHASE2
NCT01718587 UNKNOWN
Liver Cirrhosis
General Hospital of Chinese Armed Police Forces
2012-11 PHASE1; PHASE2
NCT01059422 COMPLETED
HIV Infections; Tuberculosis
Central Institute of Epidemiology, Moscow, Russia
2010-10 PHASE4
NCT01489046 TERMINATED
HIV-1 Infection
Bristol-Myers Squibb
2011-02 PHASE2
NCT01583439 TERMINATED
HIV Infections
Harvard School of Public Health (HSPH)
2012-09
NCT01088009 COMPLETED
Compensated Chronic Hepatitis B
Nanfang Hospital, Southern Medical University
2010-03 PHASE4
NCT01620944 TERMINATED
HIV
Bristol-Myers Squibb
2012-07-31 PHASE3
NCT00936195 WITHDRAWN
HIV Infection; Pregnancy; Breastfeeding; HIV Infections
French National Agency for Research on AIDS and Viral Hepatitis
2010-01 PHASE3
NCT00986778 WITHDRAWN
Hepatitis B, Chronic
Bristol-Myers Squibb
2009-12 PHASE4
NCT01139203 UNKNOWN
Liver Transplantation; Hepatitis B
Shanghai Jiao Tong University School of Medicine
2009-08
NCT01608269 COMPLETED
HiV1- Positive
Therapeutic Concepts
2010-11 PHASE4
NCT01275625 COMPLETED
HIV
ViiV Healthcare
2011-06 PHASE4
NCT00102960 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2005-07 PHASE3
NCT01622790 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
2012-06 PHASE1
NCT01487876 UNKNOWN
Chronic Hepatitis B
Fuqiang Yang
2011-09 PHASE2
NCT01788371 COMPLETED
Hepatitis B Infection; Chronic Infection; Viremia
Hua Zhang
2009-03 PHASE4
NCT01318096 UNKNOWN
HBV Coinfection; HIV Infections
Yunnan AIDS Care Center
2011-03
NCT01023217 COMPLETED
Hepatitis B, Chronic
Asan Medical Center
2009-11 PHASE4
NCT00865007 COMPLETED
HIV Infection; Lipodystrophy; HIV Infections
Fundacion SEIMC-GESIDA
2008-12 PHASE4
NCT01102972 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
2010-04 PHASE4
NCT01237444 COMPLETED
HIV Infection
Pedro Cahn
2010-12 PHASE3
NCT01270165 UNKNOWN
Chronic Hepatitis B
Yonsei University
2010-06 PHASE3
NCT00544128 COMPLETED
HIV Infections
International Medical Center of Japan
2007-10 PHASE4
NCT01294761 COMPLETED
HIV Infections
National Center for Global Health and Medicine, Japan
2011-02
NCT01546116 COMPLETED
Chronic Hepatitis B
Korea University
2010-02 PHASE4
NCT00362635 COMPLETED
Hepatitis B
Bukwang Pharmaceutical
2006-08 PHASE3
NCT01469520 UNKNOWN
HIV; AIDS
Elim Pediatric Pharmaceuticals Inc.
2010-10 PHASE1
NCT00822315 COMPLETED
HIV Infections; Tuberculosis
ANRS, Emerging Infectious Diseases
2009-07 PHASE2
NCT00737568 COMPLETED
Hepatitis B
Gilead Sciences
2008-09 PHASE3
NCT01772940 COMPLETED
HIV-1 Infection
Centre Hospitalier Universitaire Saint Pierre
2008-12 PHASE4
NCT00424814 COMPLETED
HIV Infections
ANRS, Emerging Infectious Diseases
2007-03 PHASE2; PHASE3
NCT00234091 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2006-04 PHASE3
NCT01231555 TERMINATED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
2010-11-18 PHASE2
NCT01366547 COMPLETED
Healthy Subjects; Infection, Human Immunodeficiency Virus
ViiV Healthcare
2011-06 PHASE1
NCT01014481 TERMINATED
HIV Infections; Tuberculosis
Bamrasnaradura Infectious Diseases Institute
2009-10 PHASE4
NCT01353742 COMPLETED
Hepatitis B, Chronic
GlaxoSmithKline
2011-02-21 PHASE1
NCT00724711 COMPLETED
HIV Infection
Gilead Sciences
2008-07 PHASE4
NCT00410202 COMPLETED
Hepatitis B, Chronic
Bristol-Myers Squibb
2008-03 PHASE3
NCT01220232 COMPLETED
Healthy Volunteers
Pfizer
2010-11 PHASE1
NCT00307151 COMPLETED
HIV Infections
International Maternal Pediatric Adolescent AIDS Clinical Trials Group
2005-12 PHASE2
NCT00958100 COMPLETED
HIV/AIDS; Antiretroviral Therapy; HIV Infections
Catholic University of the Sacred Heart
2009-08 PHASE2
NCT00637663 COMPLETED
Hepatitis B, Chronic
Pusan National University Hospital
2008-02 PHASE4
NCT01601899 TERMINATED
Mitochondrial Toxicity; Metabolic Complications
University of Witwatersrand, South Africa
2008-10 PHASE4
NCT00346567 COMPLETED
HIV Infections
Rigshospitalet, Denmark
2006-06
NCT00915655 COMPLETED
HIV-1 Infection
Tibotec Pharmaceuticals, Ireland
2009-07 PHASE2
NCT00440947 COMPLETED
Infection, Human Immunodeficiency Virus I; HIV Infection
ViiV Healthcare
2007-03 PHASE3
NCT00798460 TERMINATED
Chronic Hepatitis B
Inje University
2008-12 PHASE4
NCT00143728 SUSPENDED
HIV Infections
University of British Columbia
2004-01 PHASE4
NCT00084136 COMPLETED
HIV Infections
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
2005-05 PHASE4
NCT00885482 COMPLETED
HIV Infections
Catholic University of the Sacred Heart
2009-05 PHASE4
NCT00023309 COMPLETED
HBV (Hepatitis B Virus); Hepatitis B; Hepatitis
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
2001-08 PHASE2
NCT00099632 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2006-03 PHASE2
NCT00100646 COMPLETED
HIV Infections
The Wistar Institute
2007-03
NCT00951015 COMPLETED
Infection, Human Immunodeficiency Virus
ViiV Healthcare
2009-07-30 PHASE2
NCT00001644 COMPLETED
HIV Infection
National Institute of Allergy and Infectious Diseases (NIAID)
1997-03-03 PHASE1
NCT00985647 COMPLETED
HIV Infections
Kirby Institute
2009-12 PHASE1; PHASE2
NCT00662545 COMPLETED
HIV Infections; Hepatitis B
University of California, San Francisco
2008-04 PHASE4
NCT00164736 COMPLETED
HIV Infections
Centers for Disease Control and Prevention
2004-03 PHASE3
NCT00672412 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2008-10 PHASE1; PHASE2
NCT00612898 TERMINATED
HIV Infections
Avexa
2008-02 PHASE2; PHASE3
NCT01095835 COMPLETED
Hepatitis B, Chronic
Hoffmann-La Roche
2005-02 PHASE3
NCT00555334 UNKNOWN
Hepatocellular Carcinoma; Liver Cancer
Sun Yat-sen University
2007-11 PHASE4
NCT00076336 COMPLETED
Hepatitis; Hepatitis B, Chronic; Cirrhosis
Novartis Pharmaceuticals
2003-12 PHASE3
NCT01438424 COMPLETED
Hepatitis B Virus; HBV
Bristol-Myers Squibb
2001-01 PHASE2
NCT00549198 COMPLETED
Infection, Human Immunodeficiency Virus I; HIV Infection
GlaxoSmithKline
2007-06 PHASE4
NCT00625560 COMPLETED
Hepatitis B, Chronic
Yonsei University
2008-02 PHASE4
NCT00118898 COMPLETED
HIV Infections
Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
2005-09 PHASE3
NCT00470041 COMPLETED
Healthy
University Ghent
2007-06 PHASE1
NCT00615810 COMPLETED
HIV Infections
Gilead Sciences
2008-03 PHASE4
NCT00772902 COMPLETED
HIV-1
Gilead Sciences
2008-10 PHASE4
NCT00120510 COMPLETED
HIV Infections; Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
2007-07
NCT00768157 UNKNOWN
Hepatocellular Carcinoma; Hepatitis B Virus; Recurrence
Sun Yat-sen University
2007-04 PHASE4
NCT00405925 COMPLETED
HIV Infections
Rijnstate Hospital
2003-03 PHASE3
NCT00740064 UNKNOWN
HIV Infections
Denver Infectious Disease Consultants, PLLC
2008-05 PHASE4
NCT00100568 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2006-07
NCT00332306 UNKNOWN
Tuberculosis; Human Immunodeficiency Virus Infections
Tuberculosis Research Centre, India
2006-06 PHASE3
NCT00427297 TERMINATED
HIV Infections
University of Washington
2007-09 PHASE3
NCT02598063 COMPLETED
Hepatitis B, Chronic
Hoffmann-La Roche
2005-10 PHASE4
NCT00270296 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2006-06 PHASE2
NCT00307242 COMPLETED
Chronic Hepatitis B
Thomas Jefferson University
2005-06-17 PHASE4
NCT00605384 TERMINATED
Chronic Hepatitis B
Bristol-Myers Squibb
2008-08 PHASE3
NCT00255840 COMPLETED
HIV Infections
CIPRA SA
2006-07
NCT00393484 COMPLETED
Chronic Hepatitis B
Bristol-Myers Squibb
2007-02 PHASE4
NCT00146380 COMPLETED
HIV Infections
Centers for Disease Control and Prevention
2003-07 PHASE2
NCT00966160 COMPLETED
Acquired Immunodeficiency Syndrome; HIV Infections
University of Cologne
1999-01 PHASE3
NCT00380159 COMPLETED
Human Immunodeficiency Virus (HIV)-1 Infection
Alexion Pharmaceuticals, Inc.
2006-09 PHASE2
NCT00122538 COMPLETED
HIV Infections; AIDS
French National Agency for Research on AIDS and Viral Hepatitis
2006-02 PHASE2
NCT00006441 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2003-02
NCT00830856 COMPLETED
Cryptococcal Meningitis; HIV Infections
University of Zimbabwe
2006-10
NCT00312091 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2006-12 PHASE1; PHASE2
NCT00450580 COMPLETED
Infection, Human Immunodeficiency Virus I; HIV-1 Infection
ViiV Healthcare
2007-03 PHASE3
NCT00192634 COMPLETED
HIV Infections
Kirby Institute
2005-12 PHASE4
NCT01386970 COMPLETED
HIV
University of Colorado, Denver
2005-05 PHASE4
NCT00120796 TERMINATED
Hepatitis B
French National Agency for Research on AIDS and Viral Hepatitis
2005-08 PHASE3
NCT00244712 COMPLETED
HIV Infection
GlaxoSmithKline
2005-07 PHASE4
NCT00342355 COMPLETED
HIV
National Institutes of Health Clinical Center (CC)
2004-01 PHASE4
NCT00324649 COMPLETED
HIV-1
Gilead Sciences
2006-05 PHASE4
NCT00143689 COMPLETED
HIV; Mitochondrial Toxicity
University of British Columbia
2002-04 PHASE4
NCT00084149 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2004-02 PHASE2
NCT00316719 COMPLETED
Chronic Hepatitis B
GlaxoSmithKline
2006-01 PHASE3
NCT00335270 COMPLETED
HIV
Duke University
2006-03 PHASE4
NCT00312039 COMPLETED
HIV Infections
Alexion Pharmaceuticals, Inc.
2006-03-31 PHASE1; PHASE2
NCT00275652 COMPLETED
Hepatitis B; Cirrhosis
Mayo Clinic
2004-06 PHASE3
NCT00350272 COMPLETED
HIV Infections
Alexion Pharmaceuticals, Inc.
2006-05 PHASE2
NCT00006617 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00100594 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2005-05
NCT00455585 COMPLETED
HIV Infections
Makerere University
2007-01 PHASE4
NCT00098293 COMPLETED
HIV-1
ViiV Healthcare
2004-11 PHASE3
NCT00318123 COMPLETED
HIV Infections
Germans Trias i Pujol Hospital
2004-04 PHASE3
NCT00344760 COMPLETED
HIV Infections
University of Maryland, Baltimore
2005-01 PHASE4
NCT00314626 COMPLETED
HIV Infections
Germans Trias i Pujol Hospital
2004-11 PHASE3
NCT00234923 COMPLETED
HIV Infection
Abbott
2003-08 PHASE3
NCT00354653 COMPLETED
CHRONIC HEPATITIS B
ViiV Healthcare
2002-02-09 PHASE4
NCT00131742 COMPLETED
Chronic Hepatitis B
Novartis
2004-07 PHASE3
NCT00132652 COMPLETED
Chronic Hepatitis B
Novartis
2005-02 PHASE3
NCT00192621 COMPLETED
HIV Infections; Dyslipidemias; Glucose Metabolism Disorders; Metabolic Diseases; Lipodystrophy; Cardiovascular Disease
Kirby Institute
2004-11 PHASE4
NCT00041327 COMPLETED
Lymphoma
AIDS Malignancy Consortium
2002-10 PHASE2
NCT00618176 COMPLETED
HIV Infections
Peking Union Medical College
2005-01 PHASE4
NCT00084253 COMPLETED
HIV Infections
Bristol-Myers Squibb
2004-06 PHASE4
NCT00895596 COMPLETED
Chronic Hepatitis B
LG Life Sciences
2004-03 PHASE1; PHASE2
NCT00226447 COMPLETED
Chronic Hepatitis B
Chinese University of Hong Kong
2002-12 PHASE2
NCT01025830 COMPLETED
HIV/AIDS
Makerere University
2006-02 PHASE4
NCT00057265 COMPLETED
Chronic Hepatitis B
Novartis
2003-02 PHASE3
NCT00082394 COMPLETED
Infection, Human Immunodeficiency Virus I; HIV Infection
GlaxoSmithKline
2004-04-26 PHASE4
NCT00094367 COMPLETED
HIV Infection
GlaxoSmithKline
2004-07 PHASE3
NCT00335192 COMPLETED
HIV
Germans Trias i Pujol Hospital
2005-01 PHASE4
NCT00116116 COMPLETED
HIV Infections; AIDS
Bristol-Myers Squibb
2002-03 PHASE4
NCT00035789 COMPLETED
Chronic Hepatitis B
Bristol-Myers Squibb
2001-11 PHASE3
NCT00004578 COMPLETED
HIV Infections
Abbott
1997-11 PHASE1; PHASE2
NCT01022801 COMPLETED
Chronic Hepatitis B
Bristol-Myers Squibb
2003-08 PHASE2
NCT00112047 COMPLETED
HIV Infections
Gilead Sciences
2003-07 PHASE3
NCT00036608 COMPLETED
Chronic Hepatitis B
Bristol-Myers Squibb
2002-01 PHASE3
NCT01037166 COMPLETED
Chronic Hepatitis B
Bristol-Myers Squibb
2002-12 PHASE2
NCT00116298 COMPLETED
HIV Infections; AIDS
Bristol-Myers Squibb
2001-01 PHASE3
NCT00014937 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00273975 COMPLETED
HIV Infections
Boehringer Ingelheim
2002-01 PHASE2
NCT00116415 COMPLETED
HIV Infections; AIDS
Bristol-Myers Squibb
2002-03
NCT00053638 COMPLETED
HIV Infection
GlaxoSmithKline
2003-02 PHASE3
NCT00038506 COMPLETED
HIV Infection
ViiV Healthcare
2002-03 PHASE4
NCT00028327 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE3
NCT00044577 COMPLETED
Infection, Human Immunodeficiency Virus I; HIV Infection
ViiV Healthcare
2002-07-16 PHASE3
NCT00046176 COMPLETED
Infection, Human Immunodeficiency Virus I; HIV Infection
ViiV Healthcare
2002-08-26 PHASE3
NCT01982396 COMPLETED
HIV Infection
PENTA Foundation
2003-01 PHASE1
NCT00006443 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00650637 TERMINATED
Diarrhea
Pfizer
2003-01 PHASE3
NCT00013897 COMPLETED
HIV Infections
Bristol-Myers Squibb
2001-02 PHASE3
NCT00000875 TERMINATED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00124241 COMPLETED
Hepatitis B
Novartis
PHASE2
NCT00000922 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00034359 COMPLETED
Hepatitis B, Chronic
Alexion Pharmaceuticals, Inc.
2002-02 PHASE2
NCT00272480 COMPLETED
HTLV-I-associated Myelopathy
Imperial College London
1999-11-08 PHASE2; PHASE3
NCT00005918 COMPLETED
HIV Infections
Bristol-Myers Squibb
2000-06 PHASE3
NCT01421212 COMPLETED
Hepatitis B Virus Associated Liver Disease
Biotest Pharmaceuticals Corporation
1999-11 PHASE1; PHASE2
NCT00021463 COMPLETED
HIV Infections; Lipodystrophy
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00158821 COMPLETED
HIV Infections
Gilead Sciences
2000-03 PHASE3
NCT00002429 COMPLETED
HIV Infections
Bristol-Myers Squibb
1999-07 PHASE3
NCT02249130 COMPLETED
HIV Infections
Boehringer Ingelheim
1999-03 PHASE2
NCT00002411 COMPLETED
HIV Infections
Bristol-Myers Squibb
1998-03
NCT00000882 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00002371 COMPLETED
HIV Infections
Bristol-Myers Squibb
1996-06 PHASE3
NCT00004583 COMPLETED
HIV Infections
Abbott
1999-03 PHASE3
NCT00031070 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00002179 COMPLETED
HIV Infections
Merck Sharp & Dohme LLC
PHASE4
NCT00000901 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00023153 COMPLETED
HIV Infections; Chronic Hepatitis B
National Institute of Allergy and Infectious Diseases (NIAID)
2001-08 PHASE3
NCT00002386 COMPLETED
HIV Infections; Hemophilia A
Merck Sharp & Dohme LLC
PHASE4
NCT00000841 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE3
NCT00002401 COMPLETED
HIV Infections
Pharmacia and Upjohn
NCT00000944 COMPLETED
HIV Infections; Pregnancy
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00710216 WITHDRAWN
Hepatitis B, Chronic
University of Ulm
PHASE4
NCT00080522 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2005-02
NCT00034086 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00005000 UNKNOWN
HIV Infections
Agouron Pharmaceuticals
1999-12 PHASE4
NCT00002190 COMPLETED
HIV Infections
Hoffmann-La Roche
PHASE2
NCT00460850 TERMINATED
Hepatitis B, Chronic
Hoffmann-La Roche
2007-09 PHASE4
NCT00100581 COMPLETED
HIV Infections; Hepatitis C
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00043953 COMPLETED
HIV Infections
Abbott
2002-08 PHASE2
NCT00002369 COMPLETED
HIV Infections
Bristol-Myers Squibb
NCT00002423 COMPLETED
HIV Infections
Glaxo Wellcome
1999-03 PHASE2
NCT00337922 COMPLETED
HIV Infection
GlaxoSmithKline
2006-07 PHASE4
NCT00033163 COMPLETED
HIV Infections; Hepatitis B
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00002451 UNKNOWN
HIV Infections
Merck Sharp & Dohme LLC
PHASE2
NCT00000834 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00001067 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00002416 COMPLETED
HIV Infections
Triangle Pharmaceuticals
PHASE3
NCT00002442 COMPLETED
HIV Infections
Glaxo Wellcome
1999-06 PHASE2
NCT00338780 COMPLETED
Chronic Hepatitis B
Chinese University of Hong Kong
2000-11 PHASE4
NCT00051090 WITHDRAWN
HIV Infections; Hepatitis B
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00000896 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001080 WITHDRAWN
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00197613 COMPLETED
AIDS; HIV Infection
Harvard School of Public Health (HSPH)
2002-12 PHASE3
NCT00004855 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00001095 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00000872 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00120354 COMPLETED
Hepatitis B, Chronic
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
2005-07-11 PHASE4
NCT00120783 TERMINATED
HIV Infections
French National Agency for Research on AIDS and Viral Hepatitis
2002-02 PHASE2
NCT00078247 COMPLETED
HIV Infections; Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
2004-10 PHASE3
NCT00075231 COMPLETED
HIV Infections
Abbott
2003-12 PHASE2
NCT00013702 COMPLETED
Hepatitis B; HIV Infection
National Institute of Allergy and Infectious Diseases (NIAID)
2001-03 PHASE2
NCT00004585 COMPLETED
HIV Infections
Glaxo Wellcome
1999-10 PHASE4
NCT00000878 COMPLETED
HIV Infections; Pregnancy
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00005017 UNKNOWN
HIV Infections
Glaxo Wellcome
PHASE4
NCT00558493 COMPLETED
Chronic Hepatitis B
Bukwang Pharmaceutical
2007-11 PHASE4
NCT00000918 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00002227 COMPLETED
HIV Infections
Dupont Merck
PHASE2
NCT00005002 UNKNOWN
HIV Infections
Agouron Pharmaceuticals
PHASE3
NCT00122226 UNKNOWN
HIV Infections; HIV-Associated Lipodystrophy Syndrome
Amsterdam UMC, location VUmc
2003-01 PHASE4
NCT00004998 SUSPENDED
HIV Infections
Agouron Pharmaceuticals
1999-11 PHASE2
NCT00009061 UNKNOWN
HIV Infections
Glaxo Wellcome
2000-11 PHASE3
NCT00002241 UNKNOWN
HIV Infections
Merck Sharp & Dohme LLC
PHASE2
NCT00230477 COMPLETED
Hepatitis B
University of Washington
2003-04 PHASE4
NCT00001075 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00300573 TERMINATED
HIV Infections; Human Immunodeficiency Virus
Incyte Corporation
2006-04 PHASE2
NCT00002217 COMPLETED
HIV Infections
Glaxo Wellcome
NCT00004736 COMPLETED
HIV Infections; Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00000916 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00002424 SUSPENDED
HIV Infections
Merck Sharp & Dohme LLC
PHASE2
NCT00002199 COMPLETED
HIV Infections
Glaxo Wellcome
PHASE3
NCT00389194 COMPLETED
HIV Infections
International Antiviral Therapy Evaluation Center
2006-04 PHASE4
NCT00000899 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00040144 TERMINATED
Chronic Hepatitis B
Alexion Pharmaceuticals, Inc.
2002-07 PHASE2
NCT00158405 COMPLETED
HIV Infections
French National Agency for Research on AIDS and Viral Hepatitis
2002-12 PHASE3
NCT00002400 COMPLETED
HIV Infections
Pharmacia and Upjohn
NCT00380614 COMPLETED
Hepatitis B
Maulana Azad Medical College
2002-01 PHASE4
NCT00000919 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00091936 COMPLETED
HIV Infections; Tuberculosis
National Institute of Allergy and Infectious Diseases (NIAID)
2009-08
NCT00121979 COMPLETED
HIV Infections
Pharmasset
2004-09 PHASE2
NCT00000923 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00086359 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2004-07 PHASE3
NCT00000888 COMPLETED
HIV Infections; Pregnancy
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00002407 COMPLETED
HIV Infections
Weill Medical College of Cornell University
NCT00000838 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00002368 COMPLETED
HIV Infections
Boehringer Ingelheim
PHASE3
NCT00001108 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00004981 UNKNOWN
HIV Infections
Glaxo Wellcome
PHASE3
NCT00000865 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00001968 COMPLETED
Acquired Immunodeficiency Syndrome; HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
2000-01 PHASE1
NCT00001084 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00002409 COMPLETED
HIV Infections
Glaxo Wellcome
PHASE3
NCT00002410 COMPLETED
HIV Infections
Dupont Merck
PHASE3
NCT00001087 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00004999 SUSPENDED
HIV Infections
Agouron Pharmaceuticals
1999-08 PHASE2
NCT00256828 COMPLETED
HIV Infections
Clinical Trial Agency of HIV Study Group
2004-06 PHASE4
NCT00006578 WITHDRAWN
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
NCT00002233 COMPLETED
HIV Infections
Glaxo Wellcome
PHASE2
NCT00006190 COMPLETED
HIV Infections; Lipodystrophy
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
2000-11 PHASE4
NCT00014014 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00000887 COMPLETED
HIV Infections; Pregnancy
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00002108 COMPLETED
HIV Infections
Glaxo Wellcome
NCT00127972 COMPLETED
HIV Infections
International Antiviral Therapy Evaluation Center
2004-02 PHASE4
NCT00001094 WITHDRAWN
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00002155 COMPLETED
HIV Infections
Merck Sharp & Dohme LLC
NCT00489151 UNKNOWN
Hepatitis B
Hospital Authority, Hong Kong
2005-06
NCT00162643 UNKNOWN
Acquired Immunodeficiency Syndrome
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
2004-12 PHASE4
NCT00002183 COMPLETED
HIV Infections
Glaxo Wellcome
PHASE1
NCT00085943 COMPLETED
HIV Infection; Infection, Human Immunodeficiency Virus
GlaxoSmithKline
2004-05 PHASE3
NCT00000952 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00011895 UNKNOWN
HIV Infections
GlaxoSmithKline
2001-02 PHASE4
NCT00000831 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00516945 COMPLETED
Hepatitis B; Neoplasms
Hospital Authority, Hong Kong
2004-09
NCT00002184 COMPLETED
HIV Infections
Gilead Sciences
PHASE2
NCT00005764 COMPLETED
HIV Infections; Lipodystrophy
Glaxo Wellcome
2000-05 PHASE4
NCT00002162 COMPLETED
HIV Infections
Hoffmann-La Roche
PHASE2
NCT00013520 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE3
NCT00002389 COMPLETED
HIV Infections
Glaxo Wellcome
PHASE3
NCT00199979 UNKNOWN
Hiv Infection With Antiretroviral Therapy Indication; CD4 Below 350/µL or Below 15%
MEDEX
2005-04 PHASE3
NCT00002320 COMPLETED
HIV Infections
Glaxo Wellcome
PHASE3
NCT00002376 COMPLETED
HIV Infections
Merck Sharp & Dohme LLC
PHASE4
NCT00001091 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00002367 COMPLETED
HIV Infections
Hoffmann-La Roche
PHASE3
NCT00002203 COMPLETED
HIV Infections
Glaxo Wellcome
NCT00140725 COMPLETED
Chronic Hepatitis B
GlaxoSmithKline
2000-04 PHASE3
NCT00001085 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00001068 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00002379 COMPLETED
HIV Infections
Gilead Sciences
PHASE2
NCT00000940 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
1999-05 PHASE2
NCT00000891 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00000920 COMPLETED
HIV Infections; Pregnancy
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE1
NCT00002245 COMPLETED
HIV Infections
Glaxo Wellcome
1999-04 PHASE3
NCT00002378 COMPLETED
HIV Infections
Hoffmann-La Roche
PHASE3
NCT00000870 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00000885 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00201318 COMPLETED
Non-Hodgkin's Lymphoma
National Health Research Institutes, Taiwan
2001-09 PHASE2
NCT00002208 COMPLETED
HIV Infections
Merck Sharp & Dohme LLC
PHASE3
NCT00102206 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00002436 COMPLETED
HIV Infections
Glaxo Wellcome
PHASE3
NCT00001083 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE2
NCT00000903 COMPLETED
HIV Infections
National Institute of Allergy and Infectious Diseases (NIAID)
PHASE3
NCT00040157 TERMINATED
HIV Infections
Alexion Pharmaceuticals, Inc.
PHASE2
NCT00002195 COMPLETED
HIV Infections
Glaxo Wellcome
PHASE3
NCT00008554 UNKNOWN
HIV Infections
Glaxo Wellcome
2000-11 PHASE3

(data from https://clinicaltrials.gov, updated on 2026-08-14)

Check the Lamivudine (3TC, BCH-189) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Compliance for Clinical Use

Mechanism and Biochemical Profile

Lamivudine functions as a nucleoside analog reverse transcriptase inhibitor that competitively binds to HIV reverse transcriptase and hepatitis B virus DNA polymerase, incorporation of which leads to viral DNA chain termination and inhibition of viral replication. By suppressing systemic viral load and preventing cellular reinfection, this mechanistic blockade serves as a foundational therapeutic strategy in clinical investigations for managing chronic hepatitis B and human immunodeficiency virus (HIV) infections.

Appendix RUO and cGMP Quality Standards

Quality Dimension RUO (Research Use Only) cGMP (Current Good Manufacturing Practice)
Clinical Applicability Prohibited in human clinical trials or medical diagnostics. Mandatory for human clinical trials (Phase I–III) and therapies.
Regulatory Status Non-regulated grade; exempt from drug manufacturing laws. Legally enforced by health authorities (e.g., FDA, EMA, NMPA).
Facility Environment Unclassified analytical or research laboratories. Validated Cleanrooms (ISO Class 5–8) with continuous monitoring.
Quality Control Basic purity and activity testing. Rigorous safety release testing (Sterility, Endotoxin, Mycoplasma).
Process Validation Basic equipment calibration; no process validation required. Full qualification (IQ/OQ/PQ) and complete batch records.
Quality Assurance Vendor self-declared without required formal QMS. Mandatory QA/QC unit, Change Control, CAPA, and vendor audits.
Regulatory Impact High risk of IND rejection if used as a critical raw material. Required for IND/NDA filings, supported by Drug Master Files (DMF).

Footnotes

Regulatory Note: Governed by FDA (21 CFR Parts 210/211/312), EMA (EudraLex Vol 4), ICH Guidelines (E6/Q7/Q9/Q10), and compendial standards (USP <71>/<85>/<1043>).

Note: Technical data last updated: Sep 1, 2026.