CAS No. 1782235-14-6
Batch:
Purity:97.74
Chemical Structure
Check the
Laduviglusib trihydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 1782235-14-6 | |
|---|---|---|
| Molecular Formula |
C22H18Cl2N8.3ClH |
|
| Molecular Weight (MW) | 574.72 |
Laduviglusib trihydrochloride (CHIR-99021 trihydrochloride) is a potent, selective GSK-3 inhibitor targeting GSK-3α and GSK-3β, exhibiting over 500-fold selectivity over CDC2 and ERK2. Through GSK-3 inhibition, it robustly activates the Wnt/β-catenin signaling pathway, promoting the self-renewal of mouse and human embryonic stem cells and driving autophagy. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(173.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 25 mg/mL |
| Ethanol | 3 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- Laduviglusib trihydrochloride Solubility in DMSO
- Laduviglusib trihydrochloride Stock Solution
- Laduviglusib trihydrochloride Storage
- Laduviglusib trihydrochloride Stability
- Laduviglusib trihydrochloride Molecular Weight
- Laduviglusib trihydrochloride Chemical Structure (2D and 3D)
- Laduviglusib trihydrochloride SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.