CAS No. 36894-69-6
Batch:
Purity:98.51
Chemical Structure
Check the
Labetalol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 36894-69-6 | |
|---|---|---|
| Molecular Formula |
C19H24N2O3 |
|
| Molecular Weight (MW) | 328.41 |
Biological Activity
Labetalol is an orally active, selective competitive antagonist of α1-adrenergic receptors and a non-selective antagonist of β-adrenergic receptors. By dual inhibition of α1- and β-adrenergic receptor-mediated signaling, labetalol suppresses catecholamine-induced vascular constriction and cardiac rate responses, resulting in lowered systemic vascular resistance and modulation of hemodynamic parameters in cardiovascular disease models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
66 mg/mL
(200.96 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.