CAS No. 321695-57-2
Batch:
Purity:99.02
Chemical Structure
Check the
L002 (NSC764414)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | [(3,5-dimethyl-4-oxocyclohexa-2,5-dien-1-ylidene)amino] 4-methoxybenzenesulfonate | |
|---|---|---|
| CAS Number | 321695-57-2 | |
| Molecular Formula |
C15H15NO5S |
|
| Molecular Weight (MW) | 321.35 | |
| SMILES | COC1=CC=C(C=C1)[S](=O)(=O)ON=C2C=C(C)C(=O)C(=C2)C | |
| InChIKey | VEWFTYOFWIXCIO-UHFFFAOYSA-N |
Biological Activity
L002 (NSC764414) is a cell-permeable and reversible inhibitor of acetyltransferase p300 (KAT3B) with an IC50 of 1.98 μM. By targeting p300, it blocks histone acetylation and p53 acetylation while suppressing STAT3 signaling pathways. Downstream, these inhibitory functions lead to impaired cell proliferation and potent suppression of tumor growth, particularly in triple-negative breast cancer xenograft models. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
64 mg/mL
(199.15 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 4 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.