CAS No. 51-48-9
Batch:
Purity:99.26
Chemical Structure
Check the
L-Thyroxine (Levothyroxine)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid | |
|---|---|---|
| CAS Number | 51-48-9 | |
| Molecular Formula |
C15H11I4NO4 |
|
| Molecular Weight (MW) | 776.87 | |
| SMILES | C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N | |
| InChIKey | XUIIKFGFIJCVMT-LBPRGKRZSA-N |
L-Thyroxine (Levothyroxine) is a synthetic form of thyroid hormone that acts as an agonist of thyroid hormone receptors. Upon activation of these nuclear receptors, it modulates gene transcription within thyroid hormone signaling pathways, regulating cellular metabolism, growth, and differentiation. Furthermore, L-Thyroxine suppresses thyroid-stimulating hormone (TSH) secretion and is widely utilized to establish hyperthyroidism in animal models. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(128.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(128.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
| DMSO |
100 mg/mL
(128.72 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
- L-Thyroxine (Levothyroxine) Clinical Trials
- L-Thyroxine (Levothyroxine) Solubility in DMSO
- L-Thyroxine (Levothyroxine) Stock Solution
- L-Thyroxine (Levothyroxine) Storage
- L-Thyroxine (Levothyroxine) Stability
- L-Thyroxine (Levothyroxine) Molecular Weight
- L-Thyroxine (Levothyroxine) SMILES
- L-Thyroxine (Levothyroxine) Chemical Structure (2D and 3D)
- L-Thyroxine (Levothyroxine) SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.