CAS No. 98-79-3

Batch: Purity:99.87
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L-Pyroglutamic acid Chemical Structure
Chemical Structure
Check the L-Pyroglutamic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 98-79-3
Molecular Formula

C5H7NO3
Molecular Weight (MW) 129.11
SMILES C1CC(=O)NC1C(=O)O

Biological Activity

L-Pyroglutamic acid (5-oxoproline) is an endogenous cyclic amino acid metabolite derived from glutamic acid and a key intermediate in the glutathione cycle. It is converted into glutamate by 5-oxoprolinase to sustain cellular glutathione homeostasis and support amino acid transport. Through its role in central glutamatergic signaling and redox regulation, L-pyroglutamic acid influences neuronal metabolic activity, cellular antioxidant defenses, and neurotransmitter recycling processes. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 26 mg/mL (201.37 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 26 mg/mL
Ethanol 26 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Meister A. J Biol Chem. 1988;263(33):17205-8.

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Note: Technical data last updated: Sep 1, 2026.