CAS No. 1596-64-1

Batch: Purity:99.98
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L-Histidinol dihydrochloride Chemical Structure
Chemical Structure
Check the L-Histidinol dihydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-2-amino-3-(1H-imidazol-5-yl)propan-1-ol;dihydrochloride
CAS Number 1596-64-1
Molecular Formula

C6H13Cl2N3O
Molecular Weight (MW) 214.09
SMILES Cl.Cl.NC(CO)CC1=CN=C[NH]1
InChIKey FRCAFNBBXRWXQA-XRIGFGBMSA-N

Biological Activity

L-Histidinol dihydrochloride is a structural analogue of L-histidine that acts as a reversible inhibitor of protein biosynthesis. By inhibiting histidine utilization and translation, it disrupts cellular protein synthesis and evokes disparate responses in non-tumorigenic versus tumorigenic cells. This differential effect protects normal host cells from toxicity while selectively enhancing the efficacy of antineoplastic agents in cancer cells.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 43 mg/mL (200.85 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 43 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.