CAS No. 2219-31-0

Batch: Purity:100.00
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L-Canavanine sulfate Chemical Structure
Chemical Structure
Check the L-Canavanine sulfate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-2-amino-4-(diaminomethylideneamino)oxybutanoic acid;sulfuric acid
CAS Number 2219-31-0
Molecular Formula

C5H12N4O3.H2O4S
Molecular Weight (MW) 274.25
InChIKey MVIPJKVMOKFIEV-DFWYDOINSA-N

Biological Activity

L-Canavanine sulfate is a selective inhibitor of inducible nitric oxide synthase (iNOS). Functioning as an L-arginine antimetabolite, it interferes with cellular arginine metabolism and suppresses nitric oxide production. This pathway inhibition disrupts cell growth mechanisms, ultimately leading to cytotoxic effects in human carcinoma cell lines, including HeLa, Hep G2, and SK-HEP-1 cells. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 55 mg/mL
DMSO Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Bence AK, et al. Anticancer Drugs. 2002;13(3):313-20.

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Note: Technical data last updated: Sep 1, 2026.