CAS No. 253863-00-2

Batch: Purity:99.66
Check CoA
L-778123 hydrochloride Chemical Structure
Chemical Structure
Check the L-778123 hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[[5-[[4-(3-chlorophenyl)-3-oxopiperazin-1-yl]methyl]imidazol-1-yl]methyl]benzonitrile;hydrochloride
CAS Number 253863-00-2
Molecular Formula

C22H20ClN5O.ClH
Molecular Weight (MW) 442.34
InChIKey YNBSQYGTJLIPJS-UHFFFAOYSA-N

Biological Activity

L-778123 hydrochloride is a potent dual inhibitor of farnesyl protein transferase (FPTase, IC50 2 nM) and geranylgeranyl protein transferase I (GGPTase-I, IC50 98 nM). By blocking protein prenylation, it inhibits the post-translational processing of target proteins including RAS and RHO family GTPases, disrupting downstream oncogenic signaling cascades and suppressing tumor cell proliferation while displaying promising anti-leukemia activity.

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
Water 88 mg/mL
DMSO 4 mg/mL (9.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Jump to

Note: Technical data last updated: Sep 1, 2026.