CAS No. 1956356-56-1
Batch:
Purity:99.59
Chemical Structure
Check the
KYA1797K
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | potassium 3-[(5Z)-5-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]propanoate | |
|---|---|---|
| CAS Number | 1956356-56-1 | |
| Molecular Formula |
C17H11N2O6S2.K |
|
| Molecular Weight (MW) | 442.51 | |
| SMILES | C1=CC(=CC=C1C2=CC=C(O2)C=C3C(=O)N(C(=S)S3)CCC(=O)[O-])[N+](=O)[O-].[K+] | |
| InChIKey | PHUNRLYHXGMOLG-WQRRWHLMSA-M |
KYA1797K is a potent and selective Wnt/β-catenin pathway inhibitor with an IC50 ofin a TOPflash reporter assay. It directly binds to the regulator of G-protein signaling domain of Axin, enhancing Axin-GSK3β complex assembly and promoting the destruction of β-catenin and Ras proteins. Consequently, KYA1797K suppresses Wnt/β-catenin and Ras/ERK signaling, inhibiting cell proliferation and tumor growth in colorectal cancer models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
29 mg/mL
(65.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.