CAS No. 1228280-29-2
Batch:
Purity:99.72
Chemical Structure
Check the
KY-05009
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 2-anilino-5-[(4-methylbenzoyl)amino]-1,3-thiazole-4-carboxamide | |
|---|---|---|
| CAS Number | 1228280-29-2 | |
| Molecular Formula |
C18H16N4O2S |
|
| Molecular Weight (MW) | 352.41 | |
| SMILES | CC1=CC=C(C=C1)C(=O)NC2=C(N=C(NC3=CC=CC=C3)S2)C(N)=O | |
| InChIKey | WCEDGRTWDSHZHF-UHFFFAOYSA-N |
Biological Activity
KY-05009 is an ATP-competitive Traf2- and Nck-interacting kinase (TNIK) inhibitor with a Ki of 100 nM. It attenuates Wnt/β-catenin and TGF-β1-induced epithelial-to-mesenchymal transition by suppressing Smad and non-Smad signaling cascades, including NF-kB, ERK, and JNK pathways. Consequently, KY-05009 downregulates the transcriptional activity of Wnt target genes, inhibits cancer cell proliferation, and induces apoptosis in cancer cells.[1][2]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
70 mg/mL
(198.63 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.