CAS No. 2604513-16-6
Batch:
Purity:99.29
Chemical Structure
Check the
Gintemetostat
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 2604513-16-6 | |
|---|---|---|
| Molecular Formula |
C25H26F4N8O2 |
|
| Molecular Weight (MW) | 546.52 |
Gintemetostat (KTX-1001) is an orally active, potent inhibitor of NSD2 (MMSET) histone methyltransferase. By targeting the SET domain, it suppresses histone methylation and disrupts oncogenic gene transcription pathways. In preclinical models of multiple myeloma, targeted inhibition of NSD2 attenuates tumor cell growth and enhances efficacy when combined with immunomodulatory and immune-directed therapies. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(182.97 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.