CAS No. 2490284-18-7
Batch:
Purity:98.43
Chemical Structure
Check the
KT-531
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-[[cyclopropyl-(2,3,4,5-tetrafluorophenyl)sulfonylamino]methyl]-N-hydroxybenzamide | |
|---|---|---|
| CAS Number | 2490284-18-7 | |
| Molecular Formula |
C17H14F4N2O4S |
|
| Molecular Weight (MW) | 418.36 | |
| SMILES | ONC(=O)C1=CC=C(CN(C2CC2)[S;v6](=O)(=O)C3=C(F)C(=C(F)C(=C3)F)F)C=C1 | |
| InChIKey | HYEWQOQZANKATO-UHFFFAOYSA-N |
KT-531 is a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 of 8.5 nM, displaying 39-fold selectivity over other HDAC isoforms. By targeted inhibition of HDAC6, KT-531 modulates epigenetic deacetylase pathways to alter protein acetylation, ultimately suppressing cellular proliferation and inducing apoptosis in T-cell prolymphocytic leukemia and other hematological malignancy models. [1]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
84 mg/mL
(200.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.