CAS No. 2432994-31-3
Batch:
Purity:99.78
Chemical Structure
Check the
KT-474 (SAR444656)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[3-(difluoromethyl)-1-[4-[[4-[3-[1-(2,6-dioxopiperidin-3-yl)-3-methyl-2-oxobenzimidazol-4-yl]prop-2-ynoxy]piperidin-1-yl]methyl]cyclohexyl]pyrazol-4-yl]-5-[(1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptan-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide | |
|---|---|---|
| CAS Number | 2432994-31-3 | |
| Molecular Formula |
C44H49F2N11O6 |
|
| Molecular Weight (MW) | 865.93 | |
| InChIKey | NQGKNAVUMAHSQN-PKIOHZLWSA-N |
KT-474 (SAR is a selective heterobifunctional small-molecule degrader targeting interleukin-1 receptor-associated kinase 4 (IRAK4). By promoting proteasomal degradation of IRAK4, KT-474 disrupts Myddosome assembly and blocks downstream TLR/IL-1R signaling pathways. This selective depletion potently downregulates TLR7/ligand R- and lipopolysaccharide (LPS)-induced IL-and IL-cytokine production in human peripheral blood mononuclear cells (PBMCs). [1][2]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(115.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.