CAS No. 2655656-99-6
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Chemical Structure
Check the
KT-413
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-[4-[[6-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]ethyl]-2-azaspiro[3.3]heptan-2-yl]methyl]cyclohexyl]-5-(2-hydroxypropan-2-yl)-1,3-benzothiazol-6-yl]-6-(trifluoromethyl)pyridine-2-carboxamide | |
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| CAS Number | 2655656-99-6 | |
| Molecular Formula |
C45H48F3N7O6S |
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| Molecular Weight (MW) | 871.97 | |
| InChIKey | WDRJGMSUTPVXDH-UHFFFAOYSA-N |
KT-413 is a dual-function proteolysis targeting chimera (PROTAC) and molecular glue that degrades interleukin-1 receptor-associated kinase 4 (IRAK4) as well as transcription factors Ikaros and Aiolos. By promoting target protein degradation through the cereblon E3 ligase pathway, it suppresses downstream NF-kB and IRF4 signaling networks. This targeted degradation leads to strong antiproliferative effects in activated B-cell-like diffuse large B-cell lymphoma cells. [1][2]
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All in vitro solubility values are batch-tested experimental data (non-literature values).
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Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.