CAS No. 2502186-79-8

Batch: Purity:96.04
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KT-333 Chemical Structure
Chemical Structure
Check the KT-333 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [2-[[(5S,8S,10aR)-3-acetyl-8-[[(2S)-5-amino-1-[2-chloro-3-[4-[[(2S)-1-[(2S,4R)-4-hydroxy-2-[[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]carbamoyl]pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]amino]-4-oxobutyl]phenoxy]-5-oxopentan-2-yl]carbamoyl]-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocin-5-yl]carbamoyl]-1H-indole-5-carbonyl]phosphonic acid
CAS Number 2502186-79-8
Molecular Formula

C60H74ClN10O14PS
Molecular Weight (MW) 1257.78
InChIKey OANZCHOMQTZJOO-KTRCLUSBSA-N

Biological Activity

KT-333 is a potent and selective heterobifunctional degrader targeting signal transducer and activator of transcription 3 (STAT3) by recruiting the VHL E3 ligase. Targeted degradation of STAT3 downregulates downstream anti-apoptotic effectors such as MCL1, thereby suppressing survival signaling pathways. Consequently, KT-333 induces mitochondrial dysfunction and apoptosis, demonstrating robust antitumor activity in preclinical models of ALK-positive anaplastic large cell lymphoma and acute myeloid leukemia. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (79.5 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Chakraborty S, et al. Leukemia. 2026;40(4):717-729.

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Note: Technical data last updated: Sep 1, 2026.