CAS No. 2446480-97-1
Batch:
Purity:99.24
Chemical Structure
Check the
KSQ-4279 (USP1-IN-1)
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 6-(4-cyclopropyl-6-methoxypyrimidin-5-yl)-1-[[4-[1-propan-2-yl-4-(trifluoromethyl)imidazol-2-yl]phenyl]methyl]pyrazolo[3,4-d]pyrimidine | |
|---|---|---|
| CAS Number | 2446480-97-1 | |
| Molecular Formula |
C27H25F3N8O |
|
| Molecular Weight (MW) | 534.54 | |
| InChIKey | KCBWAFJCKVKYHO-UHFFFAOYSA-N |
KSQ-4279 is an orally bioavailable, selective inhibitor of ubiquitin-specific protease 1 (USP1). Inhibition of USP1 disrupts the DNA damage response by impairing deubiquitination of key substrate proteins in homologous recombination-deficient cells. This leads to compromised DNA repair pathways, accumulation of DNA damage, and antiproliferative activity, showing synergistic anti-tumor effects when combined with PARP inhibitors in homologous recombination-deficient models. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(187.07 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.