CAS No. 906669-07-6

Batch: Purity:99.99
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KPLH1130 Chemical Structure
Chemical Structure
Check the KPLH1130 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-(2,4-dihydroxyphenyl)-4-(4-methylphenyl)-1H-1,2,4-triazol-5-one
CAS Number 906669-07-6
Molecular Formula

C15H13N3O3
Molecular Weight (MW) 283.28
InChIKey UUTBMTOBGXJTLN-UHFFFAOYSA-N

Biological Activity

KPLH1130 is a small-molecule inhibitor targeting pyruvate dehydrogenase kinase (PDK). By inhibiting PDK activity, it modulates cellular metabolic pathways and regulates pyruvate dehydrogenase complex function. This targeted inhibition suppresses proinflammatory macrophage polarization, reducing downstream inflammatory cytokine expression and immune responses, thereby providing a valuable chemical tool for investigating PDK-mediated metabolic and signaling networks in inflammatory disease models.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 57 mg/mL (201.21 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.