CAS No. 1358-76-5
Batch:
Purity:99.93
Chemical Structure
Check the
Koumine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 1358-76-5 | |
|---|---|---|
| Molecular Formula |
C20H22N2O |
|
| Molecular Weight (MW) | 306.40 | |
| SMILES | CN1CC2(C3CC4C5=NC6=CC=CC=C6C52CC1C3CO4)C=C |
Biological Activity
Koumine is an indole alkaloid derived from Gelsemium elegans that exhibits analgesic, anti-inflammatory, and neurosteroid-modulating activities. It suppresses neuroinflammation by inhibiting the NF-kB signalling pathway and reducing pro-inflammatory cytokine expression. Additionally, koumine promotes neurosteroid biosynthesis in the central nervous system, contributing to its marked analgesic and anxiolytic phenotypes in animal models of neuropathic and inflammatory pain. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
15 mg/mL
(48.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
15 mg/mL
(48.95 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.