CAS No. 1695533-89-1

Batch: Purity:99.85
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KO-947 Chemical Structure
Chemical Structure
Check the KO-947 product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 6-benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,5-g]quinazolin-7-one
CAS Number 1695533-89-1
Molecular Formula

C21H17N5O

 
Molecular Weight (MW) 355.39
InChIKey ODIUJYZERXVGEI-UHFFFAOYSA-N

Biological Activity

KO-947 is a potent and selective inhibitor of ERK1/2 kinases that suppresses the MAPK signaling pathway. By directly blocking ERK1 and ERK2 catalytic activity, KO-947 disrupts downstream oncogenic signal transduction essential for tumor cell survival and proliferation. In cancer models driven by dysregulated MAPK signaling, KO-947 effectively inhibits cellular proliferation at low nanomolar concentrations. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 71 mg/mL (199.78 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Roskoski R Jr. Pharmacol Res. 2019;142:151-168.

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Note: Technical data last updated: Sep 1, 2026.