CAS No. 1956426-56-4
Batch:
Purity:99.24
Chemical Structure
Check the
KN-93 hydrochloride
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | N-[2-[[[(E)-3-(4-chlorophenyl)prop-2-enyl]-methylamino]methyl]phenyl]-N-(2-hydroxyethyl)-4-methoxybenzenesulfonamide;hydrochloride | |
|---|---|---|
| CAS Number | 1956426-56-4 | |
| Molecular Formula |
C26H29ClN2O4S.ClH |
|
| Molecular Weight (MW) | 537.50 | |
| InChIKey | ATHMCQDBXQEIOK-IPZCTEOASA-N |
KN-93 hydrochloride is a methoxybenzenesulfonamide derivative and inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with a Ki of 0.37 µM. By suppressing CaMKII activity, it prevents Ca2+-mediated phosphorylation of tyrosine hydroxylase (TH) and reduces TH reaction rates. This downstream inhibition of TH phosphorylation ultimately decreases intracellular dopamine production, demonstrating its utility in modulating Ca2+/calmodulin-dependent signaling pathways. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(186.04 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 100 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.