CAS No. 304481-60-5
Batch:
Purity:99.98
Chemical Structure
Check the
KM91104
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| IUPAC Name | 3,4-dihydroxy-N-[(2-hydroxyphenyl)methylideneamino]benzamide | |
|---|---|---|
| CAS Number | 304481-60-5 | |
| Molecular Formula |
C14H12N2O4 |
|
| Molecular Weight (MW) | 272.26 | |
| SMILES | OC1=C(O)C=C(C=C1)C(=O)NN=CC2=CC=CC=C2O | |
| InChIKey | GWVYHPUGEQGQSF-UHFFFAOYSA-N |
Biological Activity
KM91104 is a cell-permeable benzohydrazide derivative and selective vacuolar H+-ATPase (V-ATPase) inhibitor that specifically targets the interaction between V-ATPase subunits a3 and B2. By disrupting this critical protein-protein interface, KM91104 prevents functional V-ATPase complex assembly and impairs proton pump activity, leading to suppressed organellar and lysosomal acidification along with downstream inhibition of V-ATPase-dependent cellular pathways. [1]
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
54 mg/mL
(198.33 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Reference
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Note: Technical data last updated: Sep 1, 2026.