CAS No. 1369452-53-8
Batch:
Purity:98.98
Chemical Structure
Check the
KL-11743
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 2-[3-[6-ethoxy-4-[4-(1H-pyrazol-4-yl)anilino]quinazolin-2-yl]phenoxy]-N-propan-2-ylacetamide | |
|---|---|---|
| CAS Number | 1369452-53-8 | |
| Molecular Formula |
C30H30N6O3 |
|
| Molecular Weight (MW) | 522.6 | |
| InChIKey | XKOYTLRGOQTKAU-UHFFFAOYSA-N |
KL-11743 is a potent, glucose-competitive inhibitor of class I glucose transporters, including GLUT1, GLUT2, and GLUT3. By blocking cellular glucose metabolism, KL-11743 triggers an acute collapse in cellular NADH pools and a striking accumulation of aspartate, driving a metabolic shift toward mitochondrial oxidative phosphorylation. Consequently, inhibition of glucose transport with KL-11743 induces synthetic lethality when combined with mitochondrial electron transport chain inhibitors or in tricarboxylic acid cycle-deficient tumors. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(191.35 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 3 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.