CAS No. 52659-56-0
Batch:
Purity:99.82
Chemical Structure
Check the
Kirenol
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 52659-56-0 | |
|---|---|---|
| Molecular Formula |
C20H34O4 |
|
| Molecular Weight (MW) | 338.48 | |
| SMILES | CC1(CCC2C(=C1)CCC3C2(CC(CC3(C)CO)O)C)C(CO)O |
Kirenol is a natural diterpenoid isolated from Herba Siegesbeckiae that functions as an anti-inflammatory and anti-arthritic agent. It attenuates inflammatory responses by suppressing the NF-κB and MAPK signaling pathways, thereby downregulating the expression of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6. Additionally, Kirenol exhibits anti-oxidant and anti-adipogenic activities, mitigating joint inflammation and tissue damage in collagen-induced arthritis models. [1]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
68 mg/mL
(200.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| DMSO |
68 mg/mL
(200.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.